Keebaugh Andrew J, Steele Megan L, Islas-Robles Argel, Phillips Jakeb, Hilberer Allison, Cantrell Kayla, Chushak Yaroslav G, Mattie David R, Clewell Rebecca A, Merrill Elaine A
AV, Inc., Dayton, OH 45432, USA.
711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH 45433, USA.
Toxics. 2025 Aug 2;13(8):660. doi: 10.3390/toxics13080660.
Allergic contact dermatitis (ACD) is an immunologic reaction to a dermal chemical exposure that, once triggered in an individual, will result in an allergic response following subsequent encounters with the allergen. Air Force epidemiological consultations have indicated that aircraft structural maintenance workers may experience ACD at elevated rates compared to other occupations. We aimed to better understand the utility of non-animal testing methods in characterizing the sensitization potential of chemicals used during Air Force operations by evaluating the skin sensitization hazard of Air Force-relevant chemicals using new approach methodologies (NAMs) in a case study. We also evaluated the use of NAM data to develop preliminary candidate surface guidelines (PCSGs, maximum concentrations of chemicals on workplace surfaces to prevent induction of dermal sensitization) for chemicals identified as sensitizers. NAMs for assessing skin sensitization, including in silico models and experimental assays, were leveraged into an integrated approach to predict sensitization hazard for 19 chemicals. Local lymph node assay effective concentration values were predicted from NAM assay data via previously published quantitative models. The derived values were used to calculate PCSGs, which can be used to compare the presence of these chemicals on work surfaces to better understand the risk of Airmen developing ACD from occupational exposures.
过敏性接触性皮炎（ACD）是一种对皮肤化学暴露的免疫反应，一旦在个体中触发，随后再次接触过敏原时就会引发过敏反应。美国空军的流行病学咨询表明，与其他职业相比，飞机结构维修工人患ACD的比例可能更高。我们旨在通过在一个案例研究中使用新方法（NAMs）评估与空军相关化学品的皮肤致敏危害，更好地了解非动物测试方法在表征空军行动中使用的化学品致敏潜力方面的效用。我们还评估了使用NAM数据为被确定为致敏剂的化学品制定初步候选表面指南（PCSGs，工作场所表面化学品的最大浓度，以防止引起皮肤致敏）。用于评估皮肤致敏的NAMs，包括计算机模拟模型和实验分析，被整合为一种综合方法，以预测19种化学品的致敏危害。通过先前发表的定量模型，从NAM分析数据中预测局部淋巴结试验有效浓度值。导出的值用于计算PCSGs，可用于比较工作表面上这些化学品的存在情况，以更好地了解飞行员因职业暴露而患ACD的风险。
