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下一代肠道神经科学——推动该领域的未来发展。

Next-generation enteric neuroscience - fostering the future of the field.

作者信息

Muppirala Anoohya N, Ringuet Mitchell T, Benitez Alain J, Smith-Edwards Kristen M, Sharkey Keith A, Vergnolle Nathalie

机构信息

Department of Paediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Graduate Program in Neuroscience, Harvard Medical School, Boston, MA, USA.

出版信息

Nat Rev Gastroenterol Hepatol. 2025 Aug 27. doi: 10.1038/s41575-025-01102-7.

DOI:10.1038/s41575-025-01102-7
PMID:40866552
Abstract

The Little Brain Big Brain meeting was established more than 30 years ago as an opportunity for early career researchers to meet, present and discuss exciting new developments in the field of enteric neuroscience and neurogastroenterology. Crucially, the meeting is organized by young investigators, for young investigators. In this Viewpoint, past attendees and organizers of the Little Brain Big Brain meeting discuss their research interests, share their experience with this unique meeting and provide insights into progress in the field of enteric neuroscience and neurogastroenterology and its future outlook.

摘要

“小脑与大脑”会议创立于30多年前,为早期职业研究人员提供了一个交流、展示和讨论肠道神经科学与神经胃肠病学领域令人兴奋的新进展的机会。至关重要的是,该会议由年轻研究人员组织,面向年轻研究人员。在这篇观点文章中,“小脑与大脑”会议的往届参会者和组织者讨论了他们的研究兴趣,分享了他们参与这个独特会议的经验,并对肠道神经科学与神经胃肠病学领域的进展及其未来前景提供了见解。

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本文引用的文献

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Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants.
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Meta-atlas of Juvenile and Adult Enteric Neuron scRNA-seq for Dataset Comparisons and Consensus on Transcriptomic Definitions of Enteric Neuron Subtypes.用于数据集比较和肠道神经元亚型转录组定义共识的青少年和成人肠道神经元单细胞RNA测序元图谱
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Rapid cyclic stretching induces a synthetic, proinflammatory phenotype in cultured human intestinal smooth muscle, with the potential to alter signaling to adjacent bowel cells.快速周期性拉伸可诱导培养的人肠道平滑肌产生一种合成性促炎表型,有可能改变向相邻肠细胞的信号传导。
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Three-Dimensional Imaging of the Enteric Nervous System in Human Pediatric Colon Reveals New Features of Hirschsprung's Disease.人类小儿结肠肠神经系统的三维成像揭示了先天性巨结肠病的新特征。
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Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre.肠道动力在啮齿动物腰骶排便中枢作用于多巴胺、胃饥饿素和 5-羟色胺受体的部位和作用机制。
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The enteric nervous system relays psychological stress to intestinal inflammation.肠神经系统将心理压力传递给肠道炎症。
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