Qi Qiao, Hu Yongtao, Shen Qiqi, Tang Kun, Yu Jie, Xu Yuexian, Huang Qingfeng, Hou Bingbing, Hao Zongyao
Department of Urology, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, China.
Institute of Urology, Anhui Medical University, Hefei, China.
BMC Nephrol. 2025 Aug 27;26(1):495. doi: 10.1186/s12882-025-04398-4.
Our objective was to conduct a thorough evaluation of the burden of CKD and its associated anemia by age and sex at the global, regional, and national levels, with projections extending to 2050.
The data from the Global Burden of Diseases (GBD) 2021 were used to describe relevant indicators of CKD and its associated anemia. At different geographic levels, subgroup analysis was carried out by sex, age, and Socio-Demographic Index (SDI). The time trend was examined using the joinpoint regression and decomposition analyses, and predictive analysis was utilized to further estimate the disease burden to 2050.
The incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) of CKD, along with the prevalence and Years Lived with Disability (YLDs) of CKD-associated anemia, maintained a steady increase and would continue until 2050. In addition, the ASRs of mortality and DALYs attributable to CKD in 2021 were highest in low SDI regions. Regionally, CKD exhibited the greatest ASRs of mortality and DALYs in Central Latin America in 2021. Meanwhile, the disease burden of CKD and its associated anemia also showed significant differences at different national levels probably mainly due to population growth and aging. Moreover, the prediction analysis showed that the ASR of incidence attributable to CKD continued to increase.
With the global population growth and aging, the disease burden of CKD and its associated anemia is still high and varies significantly at the global, regional, and national levels, which requires healthcare professionals to refine targeted interventions.
我们的目标是在全球、区域和国家层面，按年龄和性别对慢性肾脏病（CKD）及其相关贫血的负担进行全面评估，并预测至2050年。
使用全球疾病负担（GBD）2021的数据来描述CKD及其相关贫血的相关指标。在不同地理层面，按性别、年龄和社会人口指数（SDI）进行亚组分析。使用Joinpoint回归和分解分析来研究时间趋势，并利用预测分析进一步估计到2050年的疾病负担。
CKD的发病率、患病率、死亡率和伤残调整生命年（DALY），以及CKD相关贫血的患病率和残疾生活年（YLD）均持续稳步上升，并将持续至2050年。此外，2021年低SDI地区因CKD导致的死亡率和DALY的年龄标准化率（ASR）最高。在区域层面，2021年中美洲CKD的死亡率和DALY的ASR最高。同时，CKD及其相关贫血的疾病负担在不同国家层面也存在显著差异，这可能主要归因于人口增长和老龄化。此外，预测分析表明，因CKD导致的发病率ASR持续上升。
随着全球人口增长和老龄化，CKD及其相关贫血的疾病负担仍然很高，且在全球、区域和国家层面存在显著差异，这需要医疗保健专业人员优化针对性干预措施。
