加纳耐多药病原体克隆的追踪：系统评价与荟萃分析

Tracking of multidrug-resistant pathogen clones in Ghana: a systematic review and meta-analysis.

作者信息

Odoom Alex, Donkor Eric S

机构信息

Department of Medical Microbiology, University of Ghana Medical School, P. O. Box KB 4236, Korle Bu, Accra, Ghana.

出版信息

BMC Med Genomics. 2025 Aug 27;18(1):137. doi: 10.1186/s12920-025-02161-0.

DOI:10.1186/s12920-025-02161-0

PMID:40866906

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12382024/

Abstract

INTRODUCTION

Antimicrobial resistance (AMR) threatens effective antibiotic treatment. Multidrug-resistant (MDR) bacterial clones pose a particular challenge because they facilitate rapid resistance dissemination. Tracking dominant antibiotic-resistant clones in Ghana will inform targeted surveillance and control. This systematic review characterised prevalent MDR clones of priority pathogens isolated from humans, animals, and the environment in Ghana.

METHODS

A search of PubMed, Scopus, and Web of Science databases was conducted from inception to October 4, 2024, for studies reporting genetic characterisation of MDR clones from Ghana. The risk of bias in the included studies was evaluated using the Newcastle–Ottawa scale (NOS), and data analysis involved descriptive statistics and proportional meta-analysis.

RESULTS

Twenty-five studies met the eligibility criteria, and 10 different MDR bacterial species were identified from human, animal, and environmental sources. The pooled prevalence of MDR bacteria was 53.4% (95% CI: 39.8–66.9). The dominant clones were ST155 (38.0%), ST617 (29.1%), and ST10 (11.1%). For , ST152 and ST17 were the main clones detected, each with a prevalence of 13.7%. ST39 was also present at 9.0%. The major clones were ST802 (18.5%), ST15111 (12.3%), and ST15448 (4.8%). ST152 (27.3%), ST121 (21.3%), and ST9 (14.3%) were predominant among the isolates. The most prevalent clone was ST231 (77.3%), followed by ST2145 (13.6%).

CONCLUSION

This systematic review provided the first comprehensive overview of MDR clones that may be circulating in Ghana. The identification of high-risk clones, such as ST155 and ST152, highlights the need for urgent public health interventions. Continued tracking using standardised WGS methodologies across diverse sources is crucial for guiding antimicrobial resistance containment in Ghana.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1186/s12920-025-02161-0.

摘要

引言

抗菌药物耐药性（AMR）威胁着有效的抗生素治疗。多重耐药（MDR）细菌克隆带来了特殊挑战，因为它们促进了耐药性的快速传播。追踪加纳主要的抗生素耐药克隆将为有针对性的监测和控制提供信息。本系统综述对从加纳的人类、动物和环境中分离出的重点病原体的流行多重耐药克隆进行了特征描述。

方法

检索了PubMed、Scopus和Web of Science数据库，从建库至2024年10月4日，查找报告加纳多重耐药克隆基因特征的研究。使用纽卡斯尔-渥太华量表（NOS）评估纳入研究的偏倚风险，数据分析包括描述性统计和比例荟萃分析。

结果

25项研究符合纳入标准，从人类、动物和环境来源中鉴定出10种不同的多重耐药细菌物种。多重耐药细菌的合并患病率为53.4%（95%CI：39.8 - 66.9）。主要克隆为ST155（38.0%）、ST617（29.1%）和ST10（11.1%）。对于[具体细菌名称未给出]，ST152和ST17是检测到的主要克隆，患病率均为13.7%。ST39的患病率也为9.0%。主要的[具体细菌名称未给出]克隆为ST802（18.5%）、ST15111（12.3%）和ST15448（4.8%）。ST152（27.3%）、ST121（21.3%）和ST9（14.3%）在[具体细菌名称未给出]分离株中占主导地位。最常见的[具体细菌名称未给出]克隆是ST231（77.3%），其次是ST2145（13.6%）。