Yüksel Yavuz Melike, Turan Muzaffer Onur, Özkanay Hayat, Köseoğlu Mehmet
Pulmonology Department, School of Medicine, İzmir Katip Çelebi University, 35620 İzmir, Türkiye.
Medical Biochemistry Department, School of Medicine, İzmir Katip Çelebi University, 35620 İzmir, Türkiye.
Medicina (Kaunas). 2025 Jul 24;61(8):1340. doi: 10.3390/medicina61081340.
Asthma, COPD, and asthma-COPD overlap are obstructive lung diseases with inflammation at their core. Oxidative stress and impaired antioxidant balance play a significant role in etiopathogenesis. This study aimed to determine whether there are differences in total antioxidant capacity (TAC) between asthma, COPD, and asthma-COPD overlap. A total of 76 patients participated in this prospective cross-sectional study. TAC levels in fasting venous blood samples were measured using a biochemistry analyzer and the total antioxidant activity method (Architect C1600, Abbott Laboratories, IL, USA). : TAC levels were lower in COPD patients compared to asthma and ACO patients ( = 0.049 and 0.026, respectively). TAC levels were lower in current and former smokers compared to never smokers ( = 0.033). There was no significant correlation between TAC level and eosinophil count ( = 0.597) and FEV1 and FEV1/FVC ( = 0.372 and = 0.189). : Our results suggest that TAC levels may serve as a marker to differentiate COPD from asthma or ACO.
哮喘、慢性阻塞性肺疾病（COPD）以及哮喘-COPD重叠综合征均是以炎症为核心的阻塞性肺疾病。氧化应激和抗氧化平衡受损在其发病机制中起重要作用。本研究旨在确定哮喘、COPD以及哮喘-COPD重叠综合征之间的总抗氧化能力（TAC）是否存在差异。共有76例患者参与了这项前瞻性横断面研究。使用生化分析仪和总抗氧化活性方法（美国伊利诺伊州雅培实验室的Architect C1600）测量空腹静脉血样本中的TAC水平。结果显示：与哮喘患者和哮喘-COPD重叠综合征患者相比，COPD患者的TAC水平较低（分别为P = 0.049和0.026）。与从不吸烟者相比，目前吸烟者和既往吸烟者的TAC水平较低（P = 0.033）。TAC水平与嗜酸性粒细胞计数（P = 0.597）、第一秒用力呼气容积（FEV1）以及FEV1/用力肺活量（FVC）之间无显著相关性（P = 0.372和P = 0.189）。我们的研究结果表明，TAC水平可能作为区分COPD与哮喘或哮喘-COPD重叠综合征的一个标志物。
