Basar Ahmet O, Prieto Cristina, Bardakou Evangelia, Cabedo Luis, Lagaron Jose M
Novel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology (IATA), Spanish Council for Scientific Research (CSIC), Calle Catedrático Agustín Escardino Benlloch 7, Paterna 46980, Spain.
Polymers and Advanced Materials Group (PIMA), School of Technology and Experimental Sciences, Universitat Jaume I (UJI), Avenida de Vicent Sos Baynat s/n, Castellón 12071, Spain.
ACS Appl Polym Mater. 2025 Aug 7;7(16):10416-10429. doi: 10.1021/acsapm.5c01101. eCollection 2025 Aug 22.
The present study explores the remarkable capabilities of deep eutectic solvents (DES) for enhancing the antioxidant properties of films containing the natural antioxidant resveratrol (Res). A key achievement of this work is the unprecedented solubility of resveratrol400 mg/mLin a highly effective DES composed of choline chloride (ChCl) and ethylene glycol (EG), representing a significant enhancement over previously reported values. For the active and sustainable packaging development purposes, this was coupled with the creation of continuous and nonporous electrospun poly-(3-hydroxybutyrate--3-hydroxyvalerate) (PHBV) biopaper material through electrospinning and subsequent thermal annealing processes, featuring enhanced antioxidant properties. Remarkably, a second achievement of this paper is that electrospun biopapers containing DES-solubilized Res exhibited a 30% improvement in antioxidant activity and material efficiency compared to those containing the same amount of nonsolubilized resveratrol within the polymer. Additionally, characterization was made via wide-angle X-ray diffraction, optical properties, mechanical and barrier testing, demonstrating that the studied DES not only optimized the functional attributes of PHBV biopapers but also maintained their structural integrity and mechanical and barrier performance. Therefore, this study highlights the potential of DES as a potent tool for improving the effectiveness of poorly soluble natural antioxidants, paving the way for the development of innovative solutions in active and sustainable packaging.
本研究探索了深共熔溶剂（DES）在增强含有天然抗氧化剂白藜芦醇（Res）的薄膜抗氧化性能方面的卓越能力。这项工作的一个关键成果是白藜芦醇在由氯化胆碱（ChCl）和乙二醇（EG）组成的高效DES中前所未有的溶解度——400 mg/mL，相较于先前报道的值有显著提高。为了实现活性和可持续包装的发展目标，通过静电纺丝和随后的热退火工艺，制备了连续且无孔的静电纺聚（3-羟基丁酸酯-3-羟基戊酸酯）（PHBV）生物纸材料，其具有增强的抗氧化性能。值得注意的是，本文的第二个成果是，与含有相同量聚合物内未溶解白藜芦醇的静电纺生物纸相比，含有DES溶解的Res的静电纺生物纸在抗氧化活性和材料效率方面提高了30%。此外，通过广角X射线衍射、光学性能、机械和阻隔测试进行了表征，结果表明所研究的DES不仅优化了PHBV生物纸的功能属性，还保持了其结构完整性以及机械和阻隔性能。因此，本研究突出了DES作为一种有效工具在提高难溶性天然抗氧化剂有效性方面的潜力，为活性和可持续包装领域创新解决方案的开发铺平了道路。
