Pratt M F, Schneider J, Norris M S
Microsurgery. 1985;6(4):211-8. doi: 10.1002/micr.1920060405.
Freeze-dried venous interposition allografts with an internal diameter of 1.0 mm and a length of 1.0 cm were placed into the femoral arteries of 17 Sprague-Dawley albino male rats in order to investigate patency and host tissue response. The immediate patency rate was 88%. The epigastric island flap was monitored as a sign of patency in the early postoperative period (defined as 1 to 3 days). Twelve of the 17 subjects were observed for 2 months, at which point 66% (8/12) remained patent. There were two aneurysmal dilatations. Histopathological studies and transmission electron microscopy demonstrated that freeze-dried veins undergo complete remodeling in vivo by a normal reparative process and that they do not induce a cellular immune response in the host.
将内径为1.0毫米、长度为1.0厘米的冻干静脉移植体植入17只雄性斯普拉格-道利白化大鼠的股动脉中，以研究通畅情况和宿主组织反应。即时通畅率为88%。术后早期（定义为1至3天），监测腹壁岛状皮瓣作为通畅的标志。17只实验对象中的12只被观察了2个月，此时66%（8/12）仍保持通畅。出现了两处动脉瘤样扩张。组织病理学研究和透射电子显微镜显示，冻干静脉在体内通过正常的修复过程进行完全重塑，并且它们不会在宿主中诱导细胞免疫反应。
