Liang Guohua, E Jina, Li Hanyi, Fang Zhiwen, Wang Jun, Zhan Chang'an, Yang Feng
School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, P. R. China.
Neurosurgery Center, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2025 Aug 25;42(4):693-700. doi: 10.7507/1001-5515.202411002.
The existing epilepsy seizure detection algorithms have problems such as overfitting and poor generalization ability due to high reliance on manual labeling of electroencephalogram's data and data imbalance between seizure and interictal periods. An unsupervised learning detection method for epileptic seizure that jointed graph attention network (GAT) and Transformer framework (GAT-T) was proposed. In this method, channel correlations were adaptively learned by GAT encoder. Temporal information was captured by one-dimensional convolution decoder. Combining outputs of the two mentioned above, predicted values for electroencephalogram were generated. The collective anomaly score was calculated and the detection threshold was determined. The results demonstrated that GAT-T achieved the average performance exceeding 90% (or 99%) with a 0.25 s (or 2 s) time segment length, which could effectively detect epileptic seizures. Moreover, the channel association probability matrix was expected to assist clinicians in the initial screening of the epileptogenic zone, and ablation experiments also reflected the significance of each module in GAT-T. This study may assist clinicians in making more accurate diagnostic and therapeutic decisions for epilepsy patients.
由于对脑电图数据的人工标注高度依赖以及发作期和发作间期的数据不平衡,现有的癫痫发作检测算法存在过拟合和泛化能力差等问题。提出了一种将图注意力网络(GAT)和Transformer框架相结合的癫痫发作无监督学习检测方法(GAT-T)。在该方法中,通过GAT编码器自适应学习通道相关性。通过一维卷积解码器捕获时间信息。结合上述两者的输出,生成脑电图的预测值。计算集体异常分数并确定检测阈值。结果表明,GAT-T在0.25秒(或2秒)的时间段长度下实现了超过90%(或99%)的平均性能,能够有效检测癫痫发作。此外,通道关联概率矩阵有望协助临床医生对致痫区进行初步筛查,消融实验也反映了GAT-T中各模块的重要性。本研究可能有助于临床医生为癫痫患者做出更准确的诊断和治疗决策。