Ahmed H Shafeeq
Bangalore Medical College and Research Institute, K.R Road, Bangalore, 560 002, India.
Indian J Gastroenterol. 2025 Sep 1. doi: 10.1007/s12664-025-01869-2.
Pancreatitis poses a growing health concern globally, yet its burden in India has not been comprehensively assessed over time. This study aimed to quantify the national and sub-national trends in incidence, prevalence, mortality and disability burden of pancreatitis in India from 1990 to 2021, using Global Burden of Disease (GBD) 2021 data.
Data on six core indicators: incidence, prevalence, deaths, disability-adjusted life years (DALYs), years of life lost (YLLs) and years lived with disability (YLDs) were extracted from the GBD database. Age-standardized rates (ASRs) per 100,000 population were analyzed across 31 Indian states and union territories. Trends were evaluated by age, sex and region.
From 1990 to 2021, incident cases rose from 229,614 (95% UI: 190,053-274,618) to 523,074 (95% UI: 435,284-625,178) and prevalence rose from 249,067 (95% UI: 169,900-342,317) to 547,618 (95% UI: 369,410-750,696). The age-standardized incidence rate increased modestly from 32.78 (95% UI: 27.25-38.72) to 36.76 (95% UI: 30.52-43.44), while the prevalence rate rose from 37.83 (95% UI: 25.53-51.76) to 39.70 (95% UI: 26.84-54.45). The ASR for deaths declined from 2.24 (95% UI: 1.57-3.12) to 1.71 (95% UI: 1.27-2.25) and the DALY rate from 77.69 (95% UI: 57.42-111.80) to 56.82 (95% UI: 43.50-73.46). Male ASRs remained consistently higher than female. Higher Socio-Demographic Index (SDI) states showed increased YLDs and reduced premature mortality.
The pancreatitis burden in India has increased substantially, with notable regional and sex-based differences. These findings point out the need for early diagnosis, targeted interventions in high-burden states and improved outpatient care to manage chronic morbidity.
胰腺炎在全球范围内对健康的影响日益严重，但印度胰腺炎的负担随时间推移尚未得到全面评估。本研究旨在利用全球疾病负担（GBD）2021数据，量化1990年至2021年印度胰腺炎发病率、患病率、死亡率及残疾负担的全国及次国家级趋势。
从GBD数据库中提取六个核心指标的数据：发病率、患病率、死亡人数、伤残调整生命年（DALYs）、寿命损失年数（YLLs）和残疾生存年数（YLDs）。分析了印度31个邦和联邦属地每10万人口的年龄标准化率（ASRs）。按年龄、性别和地区评估趋势。
1990年至2021年，发病病例从229,614例（95%不确定区间：190,053 - 274,618例）增至523,074例（95%不确定区间：435,284 - 625,178例），患病率从249,067例（95%不确定区间：169,900 - 342,317例）增至547,618例（95%不确定区间：369,410 - 750,696例）。年龄标准化发病率从32.78（95%不确定区间：27.25 - 38.72）略有增至36.76（95%不确定区间：30.52 - 43.44），而患病率从37.83（95%不确定区间：25.53 - 51.76）增至39.70（95%不确定区间：26.84 - 54.45）。死亡年龄标准化率从2.24（95%不确定区间：1.57 - 3.12）降至1.71（95%不确定区间：1.27 - 2.25），伤残调整生命年率从77.69（95%不确定区间：57.42 - 111.80）降至56.82（95%不确定区间：43.50 - 73.46）。男性年龄标准化率一直高于女性。社会人口指数（SDI）较高的邦残疾生存年数增加，过早死亡率降低。
印度胰腺炎负担大幅增加，存在显著的地区和性别差异。这些发现表明需要早期诊断，对高负担邦进行有针对性的干预，并改善门诊护理以管理慢性发病率。
