全球、区域和国家恶性骨和软骨肿瘤负担及趋势分析：2021 年全球疾病负担研究的系统分析。

Global, regional, and national burden and trends analysis of malignant neoplasm of bone and articular cartilage from 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021.

机构信息

Department of Orthopedic Surgery, Gaozhou People's Hospital, Gaozhou, China.

出版信息

Bone. 2024 Nov;188:117212. doi: 10.1016/j.bone.2024.117212. Epub 2024 Jul 24.

DOI:10.1016/j.bone.2024.117212

PMID:39059750

Abstract

BACKGROUND

Malignant neoplasm of bone and articular cartilage (MNBAC) is one of the causes of cancer-related deaths worldwide. To date, there is a lack of detailed studies on the disease burden of MNBAC.

METHODS

Data on the incidence, mortality, and disability-adjusted life years (DALYs) of MNBAC from 1990 to 2021 were obtained from the Global Burden of Disease study. We estimated the trends in the burden of MNBAC by calculating the estimated annual percentage change (EAPC) in age-standardized rates by region, country, and social development index.

RESULTS

Globally, the cases of incidence and deaths of MNBAC showed a significant upward trend. In 2021, the global incidence cases of MNBAC were 91,375.1 (73,780.4-102,469.7), and the number of deaths was 66,114.3 (53,305.4-74,466.9). The age-standardized incidence, mortality, and DALYs rates were all on the rise, with EAPCs of 0.59 (0.51 to 0.68), 0.11 (0.02 to 0.21), and 0.08 (0 to 0.17), respectively. In 2021, China had the highest number of incidence cases and deaths. Two peaks in incidence cases and deaths were observed in the 15-19 and 65-69 age groups, with incidence rates and death rates generally increasing with age, and higher in males than females. The region with the highest incidence cases, deaths, and age-standardized incidence rate was East Asia, while Eastern Sub-Saharan Africa had the highest age-standardized mortality, and DALYs rates.

CONCLUSION

From 1990 to 2021, the global burden of MNBAC has continued to increase, particularly in East Asia, which faces the highest number of incidence cases and deaths, while Eastern Sub-Saharan Africa faces the highest ASMR and ASDR. To mitigate this burden, different regions should develop cancer control actions based on their respective epidemiological characteristics, with a focus on the elderly and adolescents, and control of risk factors.

摘要

背景

骨和关节软骨恶性肿瘤（MNBAC）是全球癌症相关死亡的原因之一。迄今为止，关于 MNBAC 疾病负担的详细研究还很缺乏。

方法

从全球疾病负担研究中获取了 1990 年至 2021 年 MNBAC 的发病率、死亡率和伤残调整生命年（DALYs）数据。我们通过计算各地区、国家和社会发展指数的年龄标准化率的估计年百分比变化（EAPC）来估计 MNBAC 负担的趋势。

结果

全球范围内，MNBAC 的发病和死亡病例呈显著上升趋势。2021 年，MNBAC 的全球发病病例为 91375.1（73780.4-102469.7），死亡病例为 66114.3（53305.4-74466.9）。年龄标准化发病率、死亡率和 DALYs 率均呈上升趋势，EAPC 分别为 0.59（0.51-0.68）、0.11（0.02-0.21）和 0.08（0-0.17）。2021 年，中国的发病和死亡病例数均为全球最高。发病和死亡病例有两个高峰，分别出现在 15-19 岁和 65-69 岁年龄组，发病率和死亡率随年龄增长而普遍上升，且男性高于女性。发病率病例数、死亡病例数和年龄标准化发病率最高的地区是东亚，而东非撒哈拉以南地区的年龄标准化死亡率和 DALYs 率最高。