Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital, Fujian Medical University, NO. 20 Chazhong Road, Taijiang District, Fuzhou 350005, China; Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China; Fujian Provincial Clinical Research Center for Neurological Diseases, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Fujian Provincial Institutes of Brain Disorders and Brain Sciences, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Department of Neurosurgery, Neurosurgery Research Institute, the First Affiliated Hospital, Fujian Medical University, NO. 20 Chazhong Road, Taijiang District, Fuzhou 350005, China; Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China.
Seizure. 2024 Nov;122:1-9. doi: 10.1016/j.seizure.2024.09.005. Epub 2024 Sep 6.
Epilepsy, a neurological disorder, is identified by the presence of recurrent seizures. We aimed to detect dietary fiber intake and its association with epilepsy prevalence in U.S. adults.
This cross-sectional study obtained data from the 2013-2018 National Health and Nutrition Examination Survey database. Univariate and multivariate logistic regression models were employed to estimate the association between dietary fiber intake and epilepsy prevalence. The restricted cubic spline (RCS) model was also applied to investigate the dose-response relationships between dietary fiber intake and epileptic seizure events(ESEs).
Our final sample included 13,277 NHANES participants, with the average prevalence of ESEs being 1.09 % (145/13277). After adjusting for all confounding factors, the third quartile of dietary fiber intake levels remained significantly associated with a decreased risk of ESEs[odds ratios (OR) 0.54,95 % confidence interval (CI) 0.33-0.88, P = 0.014)] compared to the first quartile. Higher fiber intake indicated a stable negative association with ESEs in the multivariate logistic regression analysis, weighted generalized additive model. A nonlinear dose-response relationship was observed between dietary fiber intake levels and decreased ESEs risk (P for overall=0.017, P for nonlinear=0.155). Interaction tests showed no significant effect of demographic and disease status on the association between dietary fiber intake and ESEs.
In this cross-sectional study, people with a high dietary fiber intake were at a reduced risk of ESEs. However, further prospective studies are needed to investigate the effect of dietary fiber intake in epilepsy events and to determine causality.
癫痫是一种神经系统疾病，其特征是反复发生癫痫发作。本研究旨在检测美国成年人膳食纤维摄入量及其与癫痫患病率的关系。
本横断面研究从 2013-2018 年全国健康和营养调查数据库中获取数据。采用单因素和多因素逻辑回归模型来估计膳食纤维摄入量与癫痫患病率之间的关系。还应用受限立方样条（RCS）模型来探讨膳食纤维摄入量与癫痫发作事件（ESEs）之间的剂量-反应关系。
本研究的最终样本包括 13277 名 NHANES 参与者，ESE 的平均患病率为 1.09%（145/13277）。在调整所有混杂因素后，膳食纤维摄入量第三四分位与 ESE 风险降低显著相关[比值比（OR）0.54，95%置信区间（CI）0.33-0.88，P=0.014)]，与第一四分位相比。在多因素逻辑回归分析、加权广义加性模型中，较高的纤维摄入量与 ESE 呈稳定的负相关。在膳食纤维摄入量水平与 ESE 风险降低之间观察到非线性剂量-反应关系（总体 P=0.017，非线性 P=0.155）。交互检验显示，膳食纤维摄入量与 ESE 之间的关联不受人口统计学和疾病状况的影响。
在这项横断面研究中，膳食纤维摄入量高的人群 ESE 风险降低。然而，需要进一步的前瞻性研究来探讨膳食纤维摄入量对癫痫事件的影响，并确定因果关系。
