How Le Alicia, Lee Xin Xiang, Hui-En Sarah Ann Lee, Teo Yao Hao, Goh Kar Cheng, Tan Li Feng
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Department of Medicine, National University Hospital, National University Health System, Singapore.
J Frailty Sarcopenia Falls. 2025 Sep 1;10(3):150-156. doi: 10.22540/JFSF-10-150. eCollection 2025 Sep.
The impact of sarcopenic obesity (SO) on frailty, cognition, and function compared to sarcopenia and obesity alone remains unclear. This study examined SO's effects on these domains in community-dwelling older adults.
We assessed 202 older adults (mean age 80.4 ±7.3 years) attending a community frailty screening clinic. Obesity was defined as BMI≥25, and sarcopenia was assessed using Asian Working Group for Sarcopenia guidelines. SO was defined as the presence of both conditions. Assessments included the Clinical Frailty Scale, Modified Barthel Index, Singapore-modified Mini-Mental State Examination, and mobility aid use.
Multivariate regression showed SO was significantly associated with frailty (OR 4.71), impaired function (ß: -16.53), and mobility limitations (OR 5.73). SO was also linked to cognitive impairment (OR 3.56). Sarcopenia alone was associated with frailty (OR 3.39), impaired function (ß -11.46), and mobility limitations (OR 3.32), but not cognition. Obesity alone showed no associations. SO posed higher risks for frailty, cognitive impairment, functional decline, and mobility limitations compared to sarcopenia or obesity alone.
SO is associated with greater risks of frailty, cognitive impairment, functional decline, and mobility limitations than sarcopenia or obesity alone.
与单纯的肌肉减少症和肥胖症相比，肌少性肥胖（SO）对衰弱、认知和功能的影响尚不清楚。本研究探讨了SO对社区居住的老年人这些方面的影响。
我们评估了202名在社区衰弱筛查诊所就诊的老年人（平均年龄80.4±7.3岁）。肥胖定义为体重指数（BMI）≥25，使用亚洲肌少症工作组指南评估肌少症。SO定义为两种情况同时存在。评估包括临床衰弱量表、改良巴氏指数、新加坡改良简易精神状态检查和辅助行动器具的使用情况。
多变量回归显示，SO与衰弱（比值比[OR]4.71）、功能受损（β：-16.53）和行动能力受限（OR 5.73）显著相关。SO还与认知障碍（OR 3.56）有关。单独的肌少症与衰弱（OR 3.39）、功能受损（β -11.46）和行动能力受限（OR 3.32）有关，但与认知无关。单纯肥胖则未显示出相关性。与单独的肌少症或肥胖症相比，SO在衰弱、认知障碍、功能下降和行动能力受限方面带来的风险更高。
与单独的肌少症或肥胖症相比，SO与更高的衰弱、认知障碍、功能下降和行动能力受限风险相关。
