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本文引用的文献

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Safety analysis of compounded GLP-1 receptor agonists: a pharmacovigilance study using the FDA adverse event reporting system.复方胰高血糖素样肽-1受体激动剂的安全性分析:一项使用美国食品药品监督管理局不良事件报告系统的药物警戒研究
Expert Opin Drug Saf. 2025 Apr 29:1-8. doi: 10.1080/14740338.2025.2499670.
2
Marketing and Safety Concerns for Compounded GLP-1 Receptor Agonists.复方胰高血糖素样肽-1受体激动剂的市场与安全性问题
JAMA Health Forum. 2025 Jan 3;6(1):e245015. doi: 10.1001/jamahealthforum.2024.5015.
3
WHO Warns of Counterfeit Ozempic in the Global Supply Chain-Here's What to Know.世界卫生组织就全球供应链中的假冒司美格鲁肽发出警告——以下是你需要了解的情况。
JAMA. 2024 Aug 13;332(6):442-443. doi: 10.1001/jama.2024.13507.
4
GLP-1 shortages will not resolve this year, EMA warns, amid concern over off-label use.欧洲药品管理局警告称,由于对药品标签外使用的担忧,胰高血糖素样肽-1(GLP-1)短缺问题今年无法得到解决。
BMJ. 2024 Jun 28;385:q1448. doi: 10.1136/bmj.q1448.
5
Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis.替尔泊肽治疗代谢相关脂肪性肝炎伴肝纤维化
N Engl J Med. 2024 Jul 25;391(4):299-310. doi: 10.1056/NEJMoa2401943. Epub 2024 Jun 8.
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Virtual lab coats: The effects of verified source information on social media post credibility.虚拟实验服:已验证来源信息对社交媒体帖子可信度的影响。
PLoS One. 2024 May 29;19(5):e0302323. doi: 10.1371/journal.pone.0302323. eCollection 2024.
7
Tirzepatide: A Review in Type 2 Diabetes.替尔泊肽:用于 2 型糖尿病的治疗。
Drugs. 2024 Feb;84(2):227-238. doi: 10.1007/s40265-023-01992-4. Epub 2024 Feb 23.
8
Inequalities in the provision of GLP-1 receptor agonists for the treatment of obesity.GLP-1 受体激动剂在肥胖治疗中的提供不平等。
Nat Med. 2024 Jan;30(1):22-25. doi: 10.1038/s41591-023-02669-x.
9
Social media influencers and adolescents' health: A scoping review of the research field.社交媒体影响者与青少年健康:对该研究领域的范围综述。
Soc Sci Med. 2024 Jan;340:116387. doi: 10.1016/j.socscimed.2023.116387. Epub 2023 Nov 15.
10
GLP-1 Receptor Agonists and Related Mental Health Issues; Insights from a Range of Social Media Platforms Using a Mixed-Methods Approach.胰高血糖素样肽-1受体激动剂及相关心理健康问题:采用混合方法从一系列社交媒体平台获得的见解
Brain Sci. 2023 Oct 24;13(11):1503. doi: 10.3390/brainsci13111503.

关于胰高血糖素样肽-1药物在Instagram上有关女性健康、非传统获取途径及获取障碍的帖子中的呈现方式:内容分析

How Glucagon-Like Peptide-1 Medications Are Depicted in Instagram Posts Regarding Women's Health, Nontraditional Access, and Barriers to Access: Content Analysis.

作者信息

Bloom Brittnie E, Bragg Marie A, Jay Melanie R, Harel Daphna, Cline Camile, Crowe Matthew, Montoya Avery, Muthuramalingam Sandhya, Santana Roberto, Albert Stephanie L

机构信息

School of Public Health, College of Health and Human Services, San Diego State University, San Diego, CA, United States.

Department of Population Health, New York University Grossman School of Medicine, New York, NY, United States.

出版信息

J Med Internet Res. 2025 Sep 4;27:e66400. doi: 10.2196/66400.

DOI:10.2196/66400
PMID:40905615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12447010/
Abstract

BACKGROUND

Glucagon-like peptide-1 (GLP-1) medications, recently introduced in the United States for treating type 2 diabetes and obesity, have sparked interest and discussion on social media. Social media has emerged as a prominent platform for the distribution of health information; its vast user base and accessibility make it a popular resource for individuals seeking medical advice. This study characterized GLP-1 medication-related content on Instagram about 3 critical areas of public health: women's health, access from nontraditional settings, and barriers to access.

OBJECTIVE

This study aimed to perform passive content analysis in which information patterns would be observed from Instagram posts.

METHODS

We examined 40 GLP-1 medication-related Instagram posts to develop a list of the most frequently used hashtags. In total, 10 "top posts" were collected for 7 days (July 11-17, 2023) for 11 study hashtags (eg, #Ozempic). Duplicates, deleted posts or accounts, non-English content, and unrelated posts were removed. Each post was reviewed by at least 2 coders. Coding discrepancies were resolved through discussion.

RESULTS

The final sample included 239 posts. More than half of the posts (130/239, 54%) were from GLP-1 medication users. Raters perceived most users to be female (90/97, 92.8%); inferred that most used medications for weight loss (69/130, 53.1%); determined the most frequently noted health condition was polycystic ovarian syndrome (25/130, 19.2%); and judged posts to have positive sentiments about well-being (64/130, 49.2%) and toward the medications (100/130, 76.9%). About a quarter of the posts (55/239, 23%) offered services for obtaining GLP-1 medications; GLP-1 medications were perceived to be accessible via nontraditional health care settings (eg, medical spas) versus traditional settings (39/239,16.3% vs 12/239, 5%). Most users (78/97, 80.4%) were perceived to be White; barriers to access (ie, shortages, insurance, and cost) were infrequently mentioned (6/239, 2.5%; 3/239, 1.3%; and 1/239, 0.4%, respectively).

CONCLUSIONS

Our findings highlight the perceived benefits of GLP-1 medications for women's health, the need to increase health literacy about where to safely access medications, and how additional attention is needed for equitable access to GLP-1 medications. The onus is on social media companies to promote content that is safe and for the health care system and its payers to address health care inequities for historically marginalized communities.

摘要

背景

胰高血糖素样肽-1(GLP-1)药物最近在美国被用于治疗2型糖尿病和肥胖症,这在社交媒体上引发了关注和讨论。社交媒体已成为传播健康信息的重要平台;其庞大的用户群体和易获取性使其成为寻求医疗建议者常用的资源。本研究对Instagram上与GLP-1药物相关的内容在公共卫生的三个关键领域进行了特征描述:女性健康、非传统环境下的获取途径以及获取障碍。

目的

本研究旨在进行被动内容分析,从Instagram帖子中观察信息模式。

方法

我们检查了40条与GLP-1药物相关的Instagram帖子,以列出最常用的主题标签列表。总共为11个研究主题标签(如#Ozempic)在7天内(2023年7月11日至17日)收集了10条“热门帖子”。重复的、已删除的帖子或账户、非英文内容以及不相关的帖子均被剔除。每条帖子至少由两名编码员进行审核。编码差异通过讨论解决。

结果

最终样本包括239条帖子。超过一半的帖子(130/239,54%)来自GLP-1药物使用者。评分者认为大多数用户为女性(90/97,92.8%);推断大多数人使用该药物用于减肥(69/130,53.1%);确定最常提及的健康状况是多囊卵巢综合征(25/130,19.2%);并判断帖子对幸福感(64/130,49.2%)和对药物(100/130,76.9%)有积极情绪。约四分之一的帖子(55/239,23%)提供获取GLP-1药物的服务;人们认为GLP-1药物可通过非传统医疗保健机构(如医疗美容中心)而非传统机构获取(39/239,16.3%对12/239,5%)。大多数用户(78/97,80.4%)被认为是白人;获取障碍(即短缺、保险和费用)很少被提及(分别为6/239,2.5%;3/239,1.3%;和1/239,0.4%)。

结论

我们的研究结果凸显了GLP-1药物对女性健康的潜在益处、提高关于安全获取药物地点的健康素养的必要性,以及在公平获取GLP-1药物方面需要更多关注。社交媒体公司有责任推广安全的内容,而医疗保健系统及其支付方有责任解决历史上被边缘化社区的医疗保健不平等问题。