One Health in a globalized world: challenges and responses to zoonotic threats.

This article explores the relationship between zoonotic outbreaks and the interconnected nature of globalization through the lens of the One Health framework. It argues that global ecological changes driven by climate changes, deforestation, intensified agriculture, wildlife trade, and urban expansion have significantly elevated the risk of zoonotic disease transmission. It emphasizes how globalization has intensified some of the factors that contribute to the emergence of zoonotic outbreaks, and has also facilitated the spread of infectious diseases. Drawing on recent examples, such as the emergence of H1N1, COVID-19 and Nipah virus outbreaks, the article emphasizes the need for robust, interdisciplinary collaboration among human, animal, and environmental health sectors. The article advocates for a comprehensive global strategy rooted in the One Health approach to mitigate future zoonotic threats. It argues that this approach is based on an ethical principle of solidarity, which refers to the enacted commitment to support others based on the recognition of shared vulnerabilities or similarities. This principle is essential for collective responses to global challenges like zoonotic diseases. The One Health approach requires reinvesting in multilateral governance, enhancing wildlife and livestock surveillance, and addressing socio-environmental drivers of disease emergence, thereby promoting planetary health and global biosecurity. However, it also highlights the vulnerabilities created by nationalistic and populist policies, based on a distrust of multilateral organizations and international cooperation, and that have underfunded global health institutions, particularly affecting low-resource regions where early detection systems are lacking.