Li Liangping, Hu Guiying, Qin Wen, Liang Zhiqian, Yang Xuerong, Xing Zhiyong
School of Pharmacy, Youjiang Medical University for Nationalities, Baise, 533000, China.
School of Medical Technology and Artificial Intelligence, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China.
J Fluoresc. 2025 Sep 6. doi: 10.1007/s10895-025-04468-8.
Excessive aluminum ions (Al) contaminate environmental water bodies, and once they remain in the human body, they will pose a threat to human health. In this paper, a benzothiazole-based fluorescent sensor named BHMH for detecting Al was successfully synthesized and comprehensively characterized. It exhibited remarkable selectivity and sensitivity, manifested by a substantial fluorescence augmentation and a discernible color alteration in the presence of Al. The job plot, H NMR titration and HRMS demonstrated that the BHMH and Al complex exhibited a 1:1 stoichiometric binding affinity. Furthermore, the limit of detection (LOD) for Al was calculated as 4 × 10 M. Additionally, BHMH demonstrated successful application in the precise detection of Al across diverse aqueous samples, test papers and cell imaging within living HSC cells.
过量的铝离子（Al）污染环境水体，一旦它们留在人体中，就会对人类健康构成威胁。本文成功合成并全面表征了一种用于检测Al的基于苯并噻唑的荧光传感器BHMH。它表现出显著的选择性和灵敏度，在Al存在下表现为强烈的荧光增强和明显的颜色变化。工作曲线、1H NMR滴定和高分辨率质谱表明，BHMH与Al络合物表现出1:1的化学计量结合亲和力。此外，Al的检测限（LOD）计算为4×10 M。此外，BHMH在不同水样、试纸以及活的HSC细胞内的细胞成像中对Al的精确检测中显示出成功的应用。
