A Benzothiazole Derived Fluorescent Sensor for Real-time Detection of Aluminums Ion and Application in Real Samples and Living Cells.

Excessive aluminum ions (Al) contaminate environmental water bodies, and once they remain in the human body, they will pose a threat to human health. In this paper, a benzothiazole-based fluorescent sensor named BHMH for detecting Al was successfully synthesized and comprehensively characterized. It exhibited remarkable selectivity and sensitivity, manifested by a substantial fluorescence augmentation and a discernible color alteration in the presence of Al. The job plot, H NMR titration and HRMS demonstrated that the BHMH and Al complex exhibited a 1:1 stoichiometric binding affinity. Furthermore, the limit of detection (LOD) for Al was calculated as 4 × 10 M. Additionally, BHMH demonstrated successful application in the precise detection of Al across diverse aqueous samples, test papers and cell imaging within living HSC cells.