Department of Experimental Psychology, University of Oxford, Oxford OX2 6GG, UK.
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK; Wellcome Trust Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX2 6AE, UK.
Trends Cogn Sci. 2023 Nov;27(11):1053-1067. doi: 10.1016/j.tics.2023.08.008. Epub 2023 Aug 30.
COVID-19 is associated with a range of neurological, cognitive, and mental health symptoms both acutely and chronically that can persist for many months after infection in people with long-COVID syndrome. Investigations of cognitive function and neuroimaging have begun to elucidate the nature of some of these symptoms. They reveal that, although cognitive deficits may be related to brain imaging abnormalities in some people, symptoms can also occur in the absence of objective cognitive deficits or neuroimaging changes. Furthermore, cognitive impairment may be detected even in asymptomatic individuals. We consider the evidence regarding symptoms, cognitive deficits, and neuroimaging, as well as their possible underlying mechanisms.
COVID-19 与一系列神经、认知和心理健康症状相关，这些症状无论是在急性还是慢性感染期间都会出现，且在长新冠综合征患者中可能会持续数月。对认知功能和神经影像学的研究已经开始阐明其中一些症状的性质。它们表明，尽管认知缺陷可能与一些人的大脑影像学异常有关，但在没有客观认知缺陷或神经影像学改变的情况下，也可能出现症状。此外，甚至在无症状个体中也可能检测到认知障碍。我们考虑了关于症状、认知缺陷和神经影像学的证据，以及它们可能的潜在机制。
