用于骨重塑和抗菌应用的自组装DNA纳米载体介导的药物递送
Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applications.
作者信息
Huang Jiaqi, Chakraborty Aishik, Shamiya Yasmeen, Luo Wei, Zahid Alap Ali, Paul Arghya
机构信息
Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9 Canada.
Collaborative Specialization in Musculoskeletal Health Research and Bone and Joint Institute, The University of Western Ontario, London, ON N6A 5B9 Canada.
出版信息
NPJ Biomed Innov. 2025;2(1):29. doi: 10.1038/s44385-025-00020-2. Epub 2025 Sep 3.
We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and methicillin-resistant (MRSA) infection using in vitro studies. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility with blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy compared to free drugs in regulating bone remodeling, while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA. In the future, this nano-drug delivery platform, with its multifunctional properties, can be potentially used to treat bone fractures and surgery-related MRSA infection.
我们通过体外研究报告了一种用于治疗骨缺损和耐甲氧西林金黄色葡萄球菌（MRSA）感染的合成四面体DNA纳米载体（TDN）。我们成功合成了TDN，并证明了它们与血细胞和免疫细胞具有出色的细胞相容性。与游离药物相比，负载唑来膦酸的TDN在调节骨重塑方面显示出更高的疗效，而负载万古霉素的TDN对MRSA显示出增强的抗菌效果。未来，这种具有多功能特性的纳米药物递送平台有可能用于治疗骨折和手术相关的MRSA感染。
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