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Commentary: Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.

作者信息

Zhao Zilin, Wan Hejia, Liu Xiaohui

机构信息

School of Nursing (Nursing School of Smart Healthcare Industry), Henan University of Chinese Medicine, Zhengzhou, China.

Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Zhengzhou, China.

出版信息

Front Cell Infect Microbiol. 2025 Aug 22;15:1641826. doi: 10.3389/fcimb.2025.1641826. eCollection 2025.

DOI:10.3389/fcimb.2025.1641826
PMID:40918256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12411491/
Abstract
摘要

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Commentary: Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.述评：丙酸钠与四神丸协同治疗肾阳虚证腹泻小鼠
Front Cell Infect Microbiol. 2025 Aug 22;15:1641826. doi: 10.3389/fcimb.2025.1641826. eCollection 2025.
2
Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.丙酸钠与四神丸协同治疗肾阳虚证腹泻小鼠
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3
Commentary: Commentary: Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.述评：丙酸钠与四神丸协同治疗肾阳虚证腹泻小鼠的研究述评
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4
Commentary: Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.述评：丙酸钠与四神丸协同治疗肾阳虚证腹泻小鼠
Front Cell Infect Microbiol. 2025 Aug 13;15:1646463. doi: 10.3389/fcimb.2025.1646463. eCollection 2025.
5
One of the Short-Chain Fatty Acids (SCFAs), Sodium Propionate, Can Reduce the Dosage of Sishen Pill in Regulating the Intestinal Microbiota in Diarrhea with Kidney-Yang Deficiency Syndrome.短链脂肪酸之一的丙酸钠可降低四神丸在肾阳虚证腹泻中调节肠道菌群的剂量。
J Inflamm Res. 2025 Jun 5;18:7195-7214. doi: 10.2147/JIR.S522689. eCollection 2025.
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One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidney axis.四神丸治疗肾阳虚泄泻的作用机制之一：通过肠道微生物影响代谢功能，酶活性介导肠-肾轴。
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Effect of Sodium Butyrate and Sishen Pill Combination on Diarrhea with Kidney-Yang Deficiency Syndrome Was Associated with Intestinal Mucosal Microbiota and Immune Barrier.丁酸钠与四神丸联用对肾阳虚证腹泻的影响与肠道黏膜微生物群及免疫屏障有关。
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Intestinal mucosal flora of the intestine-kidney remediation process of diarrhea with deficiency kidney-yang syndrome in Sishen Pill treatment: Association with interactions between , Ca-Mg-ATP-ase, and Na-K-ATP-ase.四神丸治疗肾阳虚泄泻证肠-肾修复过程中肠道黏膜菌群：与Ca-Mg-ATP酶和Na-K-ATP酶之间相互作用的关联
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Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in Regulating TMAO-Mediated Inflammatory Response.针对腹泻肾阳虚证的肠-肾轴：四神丸调节 TMAO 介导的炎症反应的作用。
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本文引用的文献

1
Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.丙酸钠与四神丸协同治疗肾阳虚证腹泻小鼠
Front Cell Infect Microbiol. 2025 Jun 2;15:1608271. doi: 10.3389/fcimb.2025.1608271. eCollection 2025.
2
Flavonoid-converting capabilities of Clostridium butyricum.丁酸梭菌的类黄酮转化能力。
Appl Microbiol Biotechnol. 2025 Feb 27;109(1):53. doi: 10.1007/s00253-025-13434-0.
3
The Effects of Fatty Acids on Inflammatory Bowel Disease: A Two-Sample Mendelian Randomization Study.脂肪酸对炎症性肠病的影响：两样本孟德尔随机化研究。
Nutrients. 2022 Jul 14;14(14):2883. doi: 10.3390/nu14142883.
4
Temporal Dynamics of the Intestinal Microbiome Following Short-Term Dietary Restriction.短期饮食限制后肠道微生物组的时间动态变化。
Nutrients. 2022 Jul 6;14(14):2785. doi: 10.3390/nu14142785.
5
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines.炎症性肠病中的线粒体功能障碍改变了肠道上皮细胞对肝脏酰基辅酶 A 的代谢。
J Clin Invest. 2021 Jan 4;131(1). doi: 10.1172/JCI133371.
6
Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.四神丸对葡聚糖硫酸钠诱导的实验性结肠炎记忆性T细胞的影响
Front Pharmacol. 2020 Jul 2;11:908. doi: 10.3389/fphar.2020.00908. eCollection 2020.
7
Microbiota modulate sympathetic neurons via a gut-brain circuit.微生物群通过肠-脑回路调节交感神经元。
Nature. 2020 Jul;583(7816):441-446. doi: 10.1038/s41586-020-2474-7. Epub 2020 Jul 8.
8
Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill.基于粪便代谢组学联合 16S rRNA 基因测序分析肾阳虚证大鼠肠道菌群变化及右归丸的干预作用
J Ethnopharmacol. 2019 Nov 15;244:112139. doi: 10.1016/j.jep.2019.112139. Epub 2019 Aug 8.
9
Target Identification of Active Constituents of to Treat Kidney Deficiency Using Computational Target Fishing and Network Pharmacology.基于计算靶点筛选和网络药理学的治疗肾虚活性成分靶点鉴定
Front Pharmacol. 2019 Jun 7;10:650. doi: 10.3389/fphar.2019.00650. eCollection 2019.
10
Characteristics of mucosa-associated gut microbiota during treatment in Crohn's disease.克罗恩病治疗过程中黏膜相关肠道微生物群的特征。
World J Gastroenterol. 2019 May 14;25(18):2204-2216. doi: 10.3748/wjg.v25.i18.2204.