Behera Binodini, Choubey Shini, Kani Minu S, Satpathy Chandan Kumar
From the Department of Dermatology, Government Medical College and Hospital, Phulbani, Odisha, India.
Department of Dermatology, Kalinga Institute of Medical Sciences, Bhubaneshwar, Odisha, India.
Indian J Dermatol. 2025 Sep-Oct;70(5):295-299. doi: 10.4103/ijd.ijd_637_24. Epub 2025 Sep 1.
Entomophthoromycosis, a rare subset of chronic subcutaneous fungal infection caused by and . It predominantly affects immunocompetent individuals, mostly men. It is typically seen in tropical countries. These case reports describe two male patients a 52-year-old and a 45-year-old from eastern India with a one-year history of rhino facial swelling, initially posing a diagnostic challenge. The skin biopsy revealed granulomas, multinucleated giant cells, and a positive Splendore-Hoeppli phenomenon, supported by MRI findings indicating soft tissue thickening and enhancement confirming the diagnosis. Both the patients were successfully managed with oral itraconazole and supersaturated potassium iodide which highlighted the importance of a comprehensive diagnostic approach and appropriate antifungal therapy.
虫霉病，一种由……引起的慢性皮下真菌感染的罕见类型。它主要影响免疫功能正常的个体，以男性居多。通常见于热带国家。这些病例报告描述了两名男性患者，一名52岁，一名45岁，来自印度东部，有一年的鼻面部肿胀病史，最初构成诊断挑战。皮肤活检显示有肉芽肿、多核巨细胞以及阳性的斯普伦多-赫普勒现象，MRI结果表明软组织增厚和强化，支持了诊断。两名患者均通过口服伊曲康唑和超饱和碘化钾成功治疗，这突出了全面诊断方法和适当抗真菌治疗的重要性。
