Tessem Renae A, Dillon Alexander B, Le Boss, Hanson Justin, Hui Maggie, Anderson Lexy, Tamhaney Ami, Yu Fei, Pettenkofer Moritz S, McCannel Tara A
Ophthalmology Department, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, USA.
Vitreoretinal Surgery Service, Kaiser Permanente, Vallejo, USA.
Cureus. 2025 Aug 6;17(8):e89483. doi: 10.7759/cureus.89483. eCollection 2025 Aug.
The purpose of this study was to evaluate the effects of three brief interventions (spoken/guided meditation, nature sounds, or music) on patients' subjective experience with intravitreal injections (IVIs).
A total of 121 consecutive patients were randomized into four cohorts: spoken/guided meditation (n = 31), nature sounds (n = 30), music (classical or jazz, n = 30), and control (n = 30). Subjective anxiety levels were recorded prior to and following a three- to five-minute intervention in the first three study groups as well as following the IVI. Controls did not participate in an intervention prior to the injection. Subjective pain with the injection was recorded, as was patient satisfaction with the injection experience.
All three intervention cohorts experienced, on average, a 33% reduction in anxiety level after the intervention and prior to their IVI. While there was a trend toward lower post-intervention anxiety among those in the music cohort compared to controls, this difference did not reach statistical significance, nor was there a significant difference in pain or satisfaction across all groups, including controls. The number of prior intravitreal injections was mildly inversely correlated with pain in all subjects.
In this study, brief pre-injection music and meditation interventions demonstrated intra-cohort anxiolytic effects, though they did not prove statistically effective at reducing anxiety or influencing perceptions of pain or patient satisfaction compared to control. We encourage further investigation into non-invasive methods for reducing pain and anxiety, as well as enhancing the patient experience during ophthalmologic procedures.
本研究旨在评估三种简短干预措施（口头/引导式冥想、自然声音或音乐）对患者玻璃体内注射（IVI）主观体验的影响。
总共121名连续患者被随机分为四个队列：口头/引导式冥想组（n = 31）、自然声音组（n = 30）、音乐组（古典或爵士，n = 30）和对照组（n = 30）。在前三个研究组中，在三到五分钟的干预前后以及IVI后记录主观焦虑水平。对照组在注射前不参与干预。记录注射时的主观疼痛以及患者对注射体验的满意度。
所有三个干预队列在干预后和IVI前平均焦虑水平降低了33%。虽然与对照组相比，音乐队列中干预后的焦虑有降低趋势，但这种差异未达到统计学显著性，并且在包括对照组在内的所有组中，疼痛或满意度也没有显著差异。在所有受试者中，既往玻璃体内注射的次数与疼痛呈轻度负相关。
在本研究中，注射前简短的音乐和冥想干预在队列内显示出抗焦虑作用，尽管与对照组相比，它们在降低焦虑或影响疼痛感知或患者满意度方面未被证明具有统计学效果。我们鼓励进一步研究减少疼痛和焦虑以及改善眼科手术期间患者体验的非侵入性方法。
