Dejager D, Redlich P N, Dayer A M, Davis H L, Komorowski R A
Department of General Surgery, Medical College of Wisconsin, Milwaukee 53226, USA.
J Surg Oncol. 1995 Jul;59(3):199-203. doi: 10.1002/jso.2930590313.
Primary squamous cell carcinoma (SCC) of the breast is a rare malignancy whose optimal treatment and prognosis are unknown. A patient with SCC whose tumor responded dramatically to chemotherapy as part of multimodal treatment is presented. A 61-year-old woman had a palpable 5.5-cm tender left breast mass with overlying skin edema and erythema and irregular margins by mammography. Fine needle aspiration revealed malignant squamous cells with keratinization; incisional biopsy confirmed SCC. Extensive evaluation for an extramammary primary site of disease was negative. Neoadjuvant cisplatinum and 5-fluorouracil (5-FU) led to tumor shrinkage and complete resolution of pain and erythema. Modified radical mastectomy with post-operative chest wall radiation were performed. Neither residual invasive carcinoma nor metastatic nodal disease was found, though intraductal carcinoma with marked squamous features was identified. The patient remains disease-free 2.5 years after diagnosis. Cisplatinum-based chemotherapy should be considered in the treatment regimen of this disease.
原发性乳腺鳞状细胞癌（SCC）是一种罕见的恶性肿瘤，其最佳治疗方法和预后尚不清楚。本文介绍了一名SCC患者，其肿瘤作为多模式治疗的一部分对化疗有显著反应。一名61岁女性，左乳可触及一个5.5厘米的压痛肿块，乳房X线摄影显示肿块上方皮肤水肿、红斑，边缘不规则。细针穿刺发现有角化的恶性鳞状细胞；切取活检证实为SCC。对乳腺外疾病原发部位的广泛评估结果为阴性。新辅助顺铂和5-氟尿嘧啶（5-FU）治疗导致肿瘤缩小，疼痛和红斑完全消退。进行了改良根治性乳房切除术并术后进行胸壁放疗。尽管发现了具有明显鳞状特征的导管内癌，但未发现残留浸润性癌或转移性淋巴结疾病。患者诊断后2.5年无疾病复发。基于顺铂的化疗应纳入该病的治疗方案。
