Grahnstedt S, Ursin R
Behav Brain Res. 1985 Dec;18(3):233-9. doi: 10.1016/0166-4328(85)90031-2.
Rats were sleep deprived by the platform method to look for differential effects on light and deep slow wave sleep depending on platform size. Diameters of large and small platforms were 15 cm and 5.1 cm respectively. Sleep was recorded during a baseline light period (09.00-19.00 h), continuously during 48 h of sleep deprivation and during the first lights on recovery period (09.00-19.00 h). In both platform conditions REM sleep was virtually abolished during the first light period (hours 0-10 of sleep deprivation), while NREM sleep was reduced to approximately half of control values. During the second light period (hours 22-34 of sleep deprivation) REM sleep recovered somewhat in the large platform group. Light slow wave sleep (SWS-1) was comparable to baseline while deep slow wave sleep (SWS-2) was still significantly reduced. In the small platform group both SWS-2 and REM sleep was considerably reduced on day 2. Over the whole deprivation period there was an effect of platform size on SWS-1 (higher in the small platform group), and on SWS-2 and REM sleep (lower in the small platform group). During the 9 h light-time recovery sleep there was an REM sleep rebound in both groups. SWS-1 was reduced in both groups while SWS-2 was not significantly increased. The ratio SWS-2/SWS-1 was, however, significantly increased only in the small platform group recovery sleep. The results suggest that platform sleep deprivation deprives the animals of deep slow wave sleep in addition to REM sleep. This has implications for conclusions on REM sleep function based upon REM sleep deprivation.
采用平台法剥夺大鼠睡眠，以探究平台大小对浅睡眠和深慢波睡眠的不同影响。大平台和小平台的直径分别为15厘米和5.1厘米。在基线光照期（09:00 - 19:00）记录睡眠情况，在48小时睡眠剥夺期间持续记录，并在恢复的首个光照期（09:00 - 19:00）记录。在两种平台条件下，首个光照期（睡眠剥夺的0 - 10小时）快速眼动睡眠几乎消失，而非快速眼动睡眠减少至对照值的约一半。在第二个光照期（睡眠剥夺的22 - 34小时），大平台组的快速眼动睡眠有所恢复。浅慢波睡眠（SWS - 1）与基线相当，而深慢波睡眠（SWS - 2）仍显著减少。在小平台组，第2天SWS - 2和快速眼动睡眠均大幅减少。在整个剥夺期，平台大小对SWS - 1（小平台组较高）、SWS - 2和快速眼动睡眠（小平台组较低）有影响。在9小时的光照恢复睡眠期间，两组均出现快速眼动睡眠反弹。两组的SWS - 1均减少，而SWS - 2未显著增加。然而，SWS - 2/SWS - 1的比值仅在小平台组的恢复睡眠中显著增加。结果表明，平台睡眠剥夺除了剥夺动物的快速眼动睡眠外，还剥夺了深慢波睡眠。这对基于快速眼动睡眠剥夺得出的快速眼动睡眠功能结论有影响。
