Janoray P, Faivre J, Hillon P, Horiot J C, Ledorze C, Altwegg T, Klepping C
Bull Cancer. 1985;72(6):483-90.
The registry of digestive tract tumours established for the department of Côte-d'Or was used to study the incidence and the treatment of squamous cell cancer of the anal canal. In the course of 7 years (1976-1982), 45 new cases of anal canal cancer were recorded. Age standardized rates using world standard population are 1.3/100,000 for females, 0.3/100,000 for males. As compared to other cancer registries, Côte-d'Or is in the high range for females, in the average range for males, the cases included 44% with T1-T2 tumours (less than 4 cm), 47% with T3-T4 tumours (more than 4 cm) and 9% unknown (Tx). Lymph node involvement was found in 1/3 of cases, metastatic disease in 11%. Six patients were treated by local excision, 13 by abdomino-perineal resection (combined with postoperative radiotherapy in 5 cases), 20 by radiotherapy (combined with a derivation in 2 cases) and 6 by symptomatic treatment. For T1-T2 normal anal function was preserved in 79% of cases. The 5 year local recurrence rate for curative treatment was 44%. The 5 year observed survival rate was 42.6%; the 5 year relative survival rate was 53.3%. The survival was related to the age, to the sex, to the size of the tumour, and to the nodal status.
为科多尔省建立的消化道肿瘤登记处被用于研究肛管鳞状细胞癌的发病率和治疗情况。在7年期间（1976 - 1982年），记录了45例肛管癌新病例。使用世界标准人口计算的年龄标准化发病率，女性为1.3/10万，男性为0.3/10万。与其他癌症登记处相比，科多尔省女性发病率处于较高范围，男性处于平均范围。病例包括44%为T1 - T2期肿瘤（小于4厘米），47%为T3 - T4期肿瘤（大于4厘米），9%情况不明（Tx）。三分之一的病例发现有淋巴结受累，11%有转移性疾病。6例患者接受局部切除治疗，13例接受腹会阴联合切除术（5例术后联合放疗），20例接受放疗（2例联合改道手术），6例接受对症治疗。对于T1 - T2期肿瘤，79%的病例保留了正常肛门功能。根治性治疗的5年局部复发率为44%。5年观察生存率为42.6%；5年相对生存率为53.3%。生存率与年龄、性别、肿瘤大小和淋巴结状态有关。
