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稳定型未分化结缔组织病与中枢神经系统脱髓鞘：一例报告及文献综述

Stable Undifferentiated Connective Tissue Disease and CNS Demyelination: A Case Report and a Literature Review.

作者信息

Pachner Andrew R

机构信息

Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

出版信息

Case Rep Neurol Med. 2025 Aug 31;2025:3106627. doi: 10.1155/crnm/3106627. eCollection 2025.

DOI:10.1155/crnm/3106627
PMID:40923033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12414617/
Abstract

This patient had CNS demyelination in the context of stable undifferentiated connective tissue disease (sUCTD) and a relatively benign course despite minimal treatment. Her course is consistent with the course of similar patients described in the literature, which supports a relatively conservative approach to treatment in this group of patients.

摘要

该患者在稳定的未分化结缔组织病（sUCTD）背景下发生中枢神经系统脱髓鞘，尽管治疗极少，但病程相对良性。她的病程与文献中描述的类似患者的病程一致，这支持对该组患者采取相对保守的治疗方法。

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本文引用的文献

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Neurological Manifestations of Systemic Lupus Erythematosus: A Comprehensive Review.系统性红斑狼疮的神经学表现：综述
Cureus. 2025 Feb 24;17(2):e79569. doi: 10.7759/cureus.79569. eCollection 2025 Feb.
2
"Lupus Myelitis" Revisited: A Retrospective Single-Center Study of Myelitis Associated With Rheumatologic Disease.“狼疮性脊髓炎”再探讨：风湿性疾病相关脊髓炎的回顾性单中心研究。
Neurol Neuroimmunol Neuroinflamm. 2025 Jan;12(1):e200329. doi: 10.1212/NXI.0000000000200329. Epub 2024 Oct 23.
3
Undifferentiated Connective Tissue Disease: Comprehensive Review.未分化结缔组织病：全面综述。
Curr Rheumatol Rep. 2023 May;25(5):98-106. doi: 10.1007/s11926-023-01099-5. Epub 2023 Mar 8.
4
Interferon and interferon-induced cytokines as markers of impending clinical progression in ANA individuals without a systemic autoimmune rheumatic disease diagnosis.干扰素和干扰素诱导的细胞因子作为无系统性自身免疫性风湿病诊断的 ANA 个体即将发生临床进展的标志物。
Arthritis Res Ther. 2023 Feb 10;25(1):21. doi: 10.1186/s13075-023-02997-w.
5
Demyelinating Syndromes in Systemic Lupus Erythematosus: Data From the "Attikon" Lupus Cohort.系统性红斑狼疮中的脱髓鞘综合征：来自“阿提卡”狼疮队列的数据。
Front Neurol. 2022 May 11;13:889613. doi: 10.3389/fneur.2022.889613. eCollection 2022.
6
Disease evolution in a long-term follow-up of 104 undifferentiated connective tissue disease patients.104例未分化结缔组织病患者的长期随访中的疾病演变
Clin Exp Rheumatol. 2022 Mar;40(3):575-580. doi: 10.55563/clinexprheumatol/7vp1bo. Epub 2021 Jun 26.
7
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus.2019 年欧洲抗风湿病联盟/美国风湿病学会系统性红斑狼疮分类标准。
Arthritis Rheumatol. 2019 Sep;71(9):1400-1412. doi: 10.1002/art.40930. Epub 2019 Aug 6.
8
Coexistence of systemic lupus erythematosus and multiple sclerosis: prevalence, clinical characteristics, and natural history.红斑狼疮和多发性硬化症并存：患病率、临床特征和自然病史。
Semin Arthritis Rheum. 2014 Jun;43(6):751-8. doi: 10.1016/j.semarthrit.2013.11.007. Epub 2013 Nov 13.
9
Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity.多发性硬化严重程度评分：利用残疾情况和病程来评估疾病严重程度。
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10
An unusual case with relapsing neuromyelitis optica associated with undifferentiated connective tissue disease.一例与未分化结缔组织病相关的复发性视神经脊髓炎罕见病例。
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