Bestaoui Mohammed Hadi, Lounici Ali, Tebaibia Amar, Henaoui Latifa, Brikci-Nigassa Nawal, Baghous Houssem, Bensefia Amel
Internal Medicine Department, Tlemcen University Hospital, Tlemcen, Algeria.
Diabetes Research Laboratory, Faculty of Medicine, University of Abou Bekr Belkaid Tlemcen, Tlemcen, Algeria.
PLoS One. 2025 Sep 9;20(9):e0331867. doi: 10.1371/journal.pone.0331867. eCollection 2025.
Visceral adipose tissue (VAT) is associated with several cardiometabolic risk factors, particularly metabolic syndrome and insulin resistance. Reference values for VAT vary across populations, genders, and ages. Data on visceral fat in the Algerian population are lacking. This study aimed to establish reference values for VAT in a general adult population. The secondary objectives were to determine cardiometabolic consequences and to propose suggested threshold values for VAT to predict metabolic syndrome.
This cross-sectional, analytical study randomly selected participants from the electoral list of Tlemcen, Algeria. VAT was measured using dual-energy X-ray absorptiometry (DXA) General Electric Healthcare© Lunar iDXA.
A total of 301 adults (147 men and 154 women) with a mean age of 49.3 ± 15.1 years participated. The median (25th-75th percentiles) VAT mass was 1364 g (690-2049) in men and 1060 g (585-1590) in women. Binary logistic regression analyses demonstrated that cardiometabolic risk factors, including hypertension, type 2 diabetes, dyslipidemia, metabolic syndrome, insulin resistance according to HOMA2-IR, hepatic steatosis, and sleep apnea syndrome, were significantly dependent on VAT mass. Threshold values for VAT to predict metabolic syndrome (according to International Diabetes Federation) were ≥ 1369 g in men (sensitivity: 86.2%, specificity: 74.2%, Youden's index: 0.604) and ≥ 1082 g in women (sensitivity: 76.3%, specificity: 76.9%, Youden's index: 0.532).
This study provides reference values for VAT in an urban Algerian adult population and highlights its importance in assessing cardiometabolic risk.
内脏脂肪组织（VAT）与多种心血管代谢危险因素相关，尤其是代谢综合征和胰岛素抵抗。VAT的参考值因人群、性别和年龄而异。阿尔及利亚人群内脏脂肪的数据尚缺。本研究旨在建立一般成年人群VAT的参考值。次要目标是确定心血管代谢后果，并提出VAT预测代谢综合征的建议阈值。
本横断面分析研究从阿尔及利亚特莱姆森的选民名单中随机选取参与者。使用通用电气医疗集团（General Electric Healthcare©）的双能X线吸收法（DXA）Lunar iDXA测量VAT。
共有301名成年人（147名男性和154名女性）参与，平均年龄为49.3±15.1岁。男性VAT质量的中位数（第25-75百分位数）为1364g（690-2049），女性为1060g（585-1590）。二元逻辑回归分析表明，心血管代谢危险因素，包括高血压、2型糖尿病、血脂异常、代谢综合征、根据HOMA2-IR评估的胰岛素抵抗、肝脂肪变性和睡眠呼吸暂停综合征，均显著依赖于VAT质量。预测代谢综合征（根据国际糖尿病联盟）的VAT阈值男性≥1369g（敏感性：86.2%，特异性：74.2%，约登指数：0.604），女性≥1082g（敏感性：76.3%，特异性：76.9%，约登指数：0.532）。
本研究提供了阿尔及利亚城市成年人群VAT的参考值，并强调了其在评估心血管代谢风险中的重要性。
