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特质冲动性方面的潜在剖面分析及其与心理韧性、问题饮酒和生活质量的关联。

Latent profile analysis of trait impulsivity facets and associations with resilience, problematic alcohol use, and quality of life.

作者信息

Meyer Heidi H, Thompson Matthew F, Gunawan Tommy, Schwandt Melanie L, Ramchandani Vijay A, Diazgranados Nancy, Luk Jeremy W

机构信息

Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.

Department of Psychiatry & Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

出版信息

Alcohol Clin Exp Res (Hoboken). 2025 Oct;49(10):2365-2378. doi: 10.1111/acer.70158. Epub 2025 Sep 9.

Abstract

BACKGROUND

Impulsivity is a multidimensional construct that is associated with problematic alcohol use and alcohol use disorder (AUD). Modeling within-person clustering of impulsivity facets has the potential to aid clinical case conceptualization, and examining associations with resilience and well-being outcomes can inform strength-based intervention approaches. In this study, we utilized latent profile analysis (LPA) to capture the clustering of trait impulsivity facets and tested resilience as a mediational pathway linking impulsivity latent profiles to problematic alcohol use and quality of life domains.

METHODS

A total of 401 adults (59.9% male and 71.6% with past-year AUD) who completed self-reported measures of trait impulsivity (Barratt Impulsiveness Scale and UPPS-P Impulsive Behavior Scale), resilience, and alcohol-related outcomes were included in this study. Statistical analyses included LPA, linear regression, and path analysis.

RESULTS

LPA identified three profiles that varied by overall impulsivity as well as specific levels of negative and positive urgency: Profile 1-Low Impulsivity/Urgency (36.4%), Profile 2-Medium Impulsivity (45.6%), and Profile 3-High Impulsivity/Urgency (18.0%). The percentages of past-year AUD were 37.7% in Profile 1, 87.4% in Profile 2, and 100% in Profile 3. Latent profiles with higher impulsivity had lower resilience, higher problematic alcohol use, and lower quality of life. Low resilience was a significant mediator of associations between Medium/High Impulsivity profiles and all clinical outcomes, including problematic alcohol use and four quality of life domains.

CONCLUSIONS

In this person-centered analysis, individuals who scored high on negative urgency also had elevated scores on positive urgency and several other impulsivity facets. Within-person clustering of impulsivity facets was associated with differential risk for AUD, and latent profile differences in problematic alcohol use and quality of life outcomes were mediated by low resilience. Findings highlight resilience as a potential treatment target that warrants further evaluation in clinical research.

摘要

背景

冲动性是一个多维度的概念,与酒精使用问题和酒精使用障碍(AUD)相关。对冲动性各方面进行个体内聚类建模有可能有助于临床病例概念化,而研究其与复原力和幸福感结果的关联可以为基于优势的干预方法提供信息。在本研究中,我们利用潜在剖面分析(LPA)来捕捉特质冲动性各方面的聚类情况,并测试复原力作为连接冲动性潜在剖面与酒精使用问题和生活质量领域的中介途径。

方法

本研究纳入了401名成年人(59.9%为男性,71.6%在过去一年患有AUD),他们完成了特质冲动性(巴拉特冲动性量表和UPPS-P冲动行为量表)、复原力以及与酒精相关结果的自我报告测量。统计分析包括LPA、线性回归和路径分析。

结果

LPA识别出三种剖面,它们在总体冲动性以及消极和积极紧迫性的特定水平上存在差异:剖面1 - 低冲动性/紧迫性(36.4%),剖面2 - 中等冲动性(45.6%),剖面3 - 高冲动性/紧迫性(18.0%)。过去一年患有AUD的比例在剖面1中为37.7%,在剖面2中为87.4%,在剖面3中为100%。冲动性较高的潜在剖面具有较低的复原力、较高的酒精使用问题和较低的生活质量。低复原力是中等/高冲动性剖面与所有临床结果(包括酒精使用问题和四个生活质量领域)之间关联的重要中介因素。

结论

在这项以个体为中心的分析中,消极紧迫性得分高的个体在积极紧迫性和其他几个冲动性方面的得分也较高。冲动性各方面的个体内聚类与AUD的不同风险相关,酒精使用问题和生活质量结果的潜在剖面差异由低复原力介导。研究结果突出了复原力作为一个潜在的治疗靶点,值得在临床研究中进一步评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b66f/12519064/a72e6e1f9070/ACER-49-2365-g004.jpg

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