Matsumoto Hiroki, Kasai Takatoshi, Sato Akihiro, Shiroshita Nanako, Ishiwata Sayaki, Yatsu Shoichiro, Shitara Jun, Kato Takao, Suda Shoko, Naito Ryo, Hayashi Hidemori, Minamino Tohru, Daida Hiroyuki
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan.
Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, 113-8421 Tokyo, Japan.
Rev Cardiovasc Med. 2025 Aug 29;26(8):46143. doi: 10.31083/RCM46143. eCollection 2025 Aug.
Limited data are available regarding the prevalence of sleep-disordered breathing (SDB), particularly Cheyne-Stokes respiration (CSR), in patients with atrial fibrillation (AF) and left ventricular (LV) systolic dysfunction. Thus, this study aimed to investigate the prevalence of SDB and CSR, as well as the factors associated with these conditions, in patients with AF without LV systolic dysfunction.
Patients with paroxysmal and non-paroxysmal AF underwent echocardiography and cardiorespiratory polygraphy. Multiple linear regression analysis was performed using the apnea-hypopnea index (AHI) and %CSR as the dependent variables.
A total of 462 patients were enrolled; 335 patients (72.5%) were diagnosed with SDB (AHI ≥5/h), with a median AHI of 10.3 events per hour (interquartile range, 4.7-20.8). CSR was observed in 107 patients (23.2%). Multiple linear regression analysis showed that age, sex, body mass index, and hypertension were independently correlated with AHI ( = 0.0188, 0.0002, <0.0001, and 0.0457, respectively). Conversely, age, diabetes mellitus (DM), and the plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) level were independently correlated with %CSR ( < 0.0001, 0.0047, and 0.0095, respectively).
SDB and CSR were common in patients with AF. CSR was observed in older patients with DM and high NT-proBNP levels.
关于心房颤动（AF）和左心室（LV）收缩功能障碍患者睡眠呼吸障碍（SDB），尤其是潮式呼吸（CSR）的患病率，现有数据有限。因此，本研究旨在调查无LV收缩功能障碍的AF患者中SDB和CSR的患病率，以及与这些情况相关的因素。
阵发性和非阵发性AF患者接受了超声心动图和心肺多导睡眠图检查。以呼吸暂停低通气指数（AHI）和CSR百分比作为因变量进行多元线性回归分析。
共纳入462例患者；335例患者（72.5%）被诊断为SDB（AHI≥5次/小时），AHI中位数为每小时10.3次事件（四分位间距，4.7 - 20.8）。107例患者（23.2%）观察到CSR。多元线性回归分析显示，年龄、性别、体重指数和高血压与AHI独立相关（分别为 = 0.0188、0.0002、<0.0001和0.0457）。相反，年龄、糖尿病（DM）和血浆脑钠肽前体N末端（NT-proBNP）水平与CSR百分比独立相关（分别为<0.0,001、0.0047和0.0095）。
SDB和CSR在AF患者中很常见。在患有DM且NT-proBNP水平高的老年患者中观察到CSR。
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