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不同严重程度支原体肺炎患儿肺功能和免疫功能的动态变化及其对疾病预后的预测价值：一项回顾性队列研究

Dynamic changes of pulmonary function and immune function in children with mycoplasma pneumonia of different severity and their predictive value for disease prognosis: a retrospective cohort study.

作者信息

Liu Zheng, Deng Wen, Xu Wenlin, Ye Linlin, Rao Zhihui

机构信息

Department of Respiratory, Children's Hospital of Chongqing Medical University, Chongqing, China.

Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Front Med (Lausanne). 2025 Aug 26;12:1624256. doi: 10.3389/fmed.2025.1624256. eCollection 2025.

DOI:10.3389/fmed.2025.1624256
PMID:40933568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12419223/
Abstract

PURPOSE

To explore the dynamic changes in pulmonary and immune function among children with Mycoplasma pneumoniae pneumonia (MPP) and evaluate their value in disease severity stratification and prognosis prediction.

METHOD

A retrospective cohort of 225 pediatric patients with varying degrees of MPP severity and disease course was analyzed. Lung function and immunological indices were measured and compared across groups.

RESULTS

Children with MPP exhibited significant impairments in pulmonary function and alterations in immune profiles compared to controls. These changes were associated with both disease severity and recovery status.

CONCLUSION

Pulmonary and immune function markers may serve as useful indicators for assessing severity and recovery in pediatric MPP. Their clinical application could improve individualized management strategies.

摘要

目的

探讨肺炎支原体肺炎（MPP）患儿肺功能和免疫功能的动态变化，并评估其在疾病严重程度分层和预后预测中的价值。

方法

对225例不同严重程度和病程的MPP患儿进行回顾性队列分析。测量并比较各组的肺功能和免疫指标。

结果

与对照组相比，MPP患儿的肺功能有显著损害，免疫谱也有改变。这些变化与疾病严重程度和恢复状态均相关。

结论

肺功能和免疫功能指标可作为评估小儿MPP严重程度和恢复情况的有用指标。它们的临床应用可改善个体化管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/a9a737de9bba/fmed-12-1624256-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/48bc0384f442/fmed-12-1624256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/243e8947c9ea/fmed-12-1624256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/e206ba7482e5/fmed-12-1624256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/a5792b0c9990/fmed-12-1624256-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/a9a737de9bba/fmed-12-1624256-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/48bc0384f442/fmed-12-1624256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/243e8947c9ea/fmed-12-1624256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/e206ba7482e5/fmed-12-1624256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/a5792b0c9990/fmed-12-1624256-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/12419223/a9a737de9bba/fmed-12-1624256-g005.jpg

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本文引用的文献

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Immunol Res. 2024 Dec 23;73(1):24. doi: 10.1007/s12026-024-09576-4.
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Design of a novel multiepitope vaccine with CTLA-4 extracellular domain against Mycoplasma pneumoniae: A vaccine-immunoinformatics approach.设计一种新型 CTLA-4 细胞外域多表位疫苗以对抗肺炎支原体：疫苗免疫信息学方法。
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Predictive value of lactate dehydrogenase for Mycoplasma pneumoniae necrotizing pneumonia in children based on decision curve analysis and dose-response analysis.
基于决策曲线分析和剂量反应分析的乳酸脱氢酶对儿童肺炎支原体坏死性肺炎的预测价值。
Sci Rep. 2024 Apr 29;14(1):9803. doi: 10.1038/s41598-024-60359-1.
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Wuhu decoction combined with azithromycin for treatment of pneumoniae pneumonia in Asian children: a systematic review and meta analysis of randomized controlled trials.芜湖汤联合阿奇霉素治疗亚洲儿童肺炎支原体肺炎：一项随机对照试验的系统评价和荟萃分析
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Integrative study of pulmonary microbiome, transcriptome and clinical outcomes in Mycoplasma pneumoniae pneumonia.肺炎支原体肺炎的肺微生物组、转录组与临床结局的综合研究。
Respir Res. 2024 Jan 18;25(1):35. doi: 10.1186/s12931-024-02687-4.
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Long-term follow-up of Mycoplasma hyopneumoniae-specific immunity in vaccinated pigs.接种猪肺炎支原体疫苗后特异性免疫的长期随访。
Vet Res. 2023 Mar 1;54(1):16. doi: 10.1186/s13567-023-01145-1.
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