不同严重程度支原体肺炎患儿肺功能和免疫功能的动态变化及其对疾病预后的预测价值：一项回顾性队列研究

Dynamic changes of pulmonary function and immune function in children with mycoplasma pneumonia of different severity and their predictive value for disease prognosis: a retrospective cohort study.

作者信息

Liu Zheng, Deng Wen, Xu Wenlin, Ye Linlin, Rao Zhihui

机构信息

Department of Respiratory, Children's Hospital of Chongqing Medical University, Chongqing, China.

Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Front Med (Lausanne). 2025 Aug 26;12:1624256. doi: 10.3389/fmed.2025.1624256. eCollection 2025.

PURPOSE

To explore the dynamic changes in pulmonary and immune function among children with Mycoplasma pneumoniae pneumonia (MPP) and evaluate their value in disease severity stratification and prognosis prediction.

METHOD

A retrospective cohort of 225 pediatric patients with varying degrees of MPP severity and disease course was analyzed. Lung function and immunological indices were measured and compared across groups.

RESULTS

Children with MPP exhibited significant impairments in pulmonary function and alterations in immune profiles compared to controls. These changes were associated with both disease severity and recovery status.

CONCLUSION

Pulmonary and immune function markers may serve as useful indicators for assessing severity and recovery in pediatric MPP. Their clinical application could improve individualized management strategies.