Hayreh S S
Arch Ophthalmol. 1977 Sep;95(9):1566-79. doi: 10.1001/archopht.1977.04450090088007.
The pattern and pathogenesis of nonlocalizing visual disturbances, associated with optic disc edema (ODE). raised cerebrospinal fluid pressure, and intracranial space-taking lesions were investigated experimentally in rhesus monkeys with simulated progressive brain tumor and clinically in patients with benign intracranial hypertension. The visual disturbances occurring in one of both eyes were of three types: recurrent attacks of transient obscuration, permanent blindness, and various types of visual field defects. The studies indicate that the visual disturbances are usually due to two mechanisms. The most common is ischemia of the optic disc secondary to ODE. The other, rarer mechanism probably consists of the space-taking lesion causing downward herniation of the parahippocampal gyrus into the tentorial notch, producing compression of the lateral geniculate body and optic tract.
对伴有视盘水肿（ODE）、脑脊液压力升高和颅内占位性病变的非定位性视觉障碍的模式和发病机制，在患有模拟进行性脑肿瘤的恒河猴身上进行了实验研究，并在患有良性颅内高压的患者身上进行了临床研究。单眼或双眼出现的视觉障碍有三种类型：短暂性黑矇的反复发作、永久性失明和各种类型的视野缺损。研究表明，视觉障碍通常由两种机制引起。最常见的是继发于视盘水肿的视盘缺血。另一种较罕见的机制可能是占位性病变导致海马旁回向下疝入小脑幕切迹，压迫外侧膝状体和视束。
