Guerrini Usubini Anna, Marazzi Nicoletta, Abbruzzese Laura, Bondesan Adele, Grugni Graziano, Castelnuovo Gianluca, Sartorio Alessandro
Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), 28824 Piancavallo-Verbania, Italy.
Division of Auxology, Istituto Auxologico Italiano, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), 28824 Piancavallo-Verbania, Italy.
Healthcare (Basel). 2025 Sep 4;13(17):2213. doi: 10.3390/healthcare13172213.
BACKGROUND/OBJECTIVES: This study aimed to evaluate quality of life in children and adolescents with normal variants of short stature compared to age- and sex-matched individuals with normal stature and to assess the agreement between children/adolescents-reported and parent-reported outcomes.
A total of 65 child-parent dyads were enrolled, including 29 children and adolescents with short stature (15 males, 14 females; mean age: 11.2 + 2.0 years; mean height standard deviation score, HSDS: -2.10 + 0.57) and 36 children and adolescents with normal stature (19 males, 17 females; mean age: 11.3 + 1.93 years; mean HSDS: 0.56 + 0.78). Quality of life was assessed using the Quality of Life in Short Stature Youth (QoLISSY) questionnaire. Statistical analyses included independent samples -tests, and effect sizes were computed using Cohen's .
Among short-statured children and adolescents, no significant correlations were found between HSDS and all domains of quality of life. Short-statured children and adolescents exhibited significantly lower QoL across all domains compared to their normal-statured peers. Coping was higher in children and adolescents with short stature compared to their peers of normal stature. Similarly, parents of short-statured children and adolescents perceived a lower QoL for their sons and daughters and reported greater concern about the future and a more perceived personal impact than parents of normal-statured children and adolescents. No statistically significant differences were found between sons/daughters and parent reports, indicating a relatively high level of agreement in quality of life (QoL) perceptions.
These findings underscore the psychosocial impact of short stature and highlight the importance of incorporating both child and parent perspectives in the clinical assessment.
背景/目的：本研究旨在评估身材矮小正常变异的儿童和青少年与年龄及性别匹配的正常身材个体的生活质量，并评估儿童/青少年报告结果与家长报告结果之间的一致性。
共纳入65对儿童-家长二元组，其中包括29名身材矮小的儿童和青少年（15名男性，14名女性；平均年龄：11.2±2.0岁；平均身高标准差评分，HSDS：-2.10±0.57）以及36名正常身材的儿童和青少年（19名男性，17名女性；平均年龄：11.3±1.93岁；平均HSDS：0.56±0.78）。使用矮小身材青少年生活质量（QoLISSY）问卷评估生活质量。统计分析包括独立样本t检验，并使用科恩d计算效应量。
在身材矮小的儿童和青少年中，未发现HSDS与生活质量的所有领域之间存在显著相关性。与正常身材的同龄人相比，身材矮小的儿童和青少年在所有领域的生活质量均显著较低。身材矮小的儿童和青少年的应对能力高于正常身材的同龄人。同样，身材矮小的儿童和青少年的父母认为其子女的生活质量较低，并且与正常身材儿童和青少年的父母相比，他们对未来更担忧，且更多地感受到个人影响。在子女报告与家长报告之间未发现统计学上的显著差异，表明在生活质量（QoL）认知方面具有较高的一致性。
这些发现强调了身材矮小对心理社会的影响，并突出了在临床评估中纳入儿童和家长观点的重要性。
