Artificial Intelligence-Based MRI Segmentation for the Differential Diagnosis of Single Brain Metastasis and Glioblastoma.

: Glioblastomas (GBMs) and brain metastases (BMs) are both frequent brain lesions. Distinguishing between them is crucial for suitable therapeutic and follow-up decisions, but this distinction is difficult to achieve, as it includes clinical, radiological and histopathological correlation. However, non-invasive AI examination of conventional and advanced MRI techniques can overcome this issue. : We retrospectively selected 78 patients with confirmed GBM (39) and single BM (39), with conventional MRI investigations, consisting of T2W FLAIR and CE T1W acquisitions. The MRI images (DICOM) were evaluated by an AI segmentation tool, comparatively evaluating tumor heterogeneity and peripheral edema. : We found that GBMs are less edematous than BMs ( = 0.04) but have more internal necrosis ( = 0.002). Of the BM primary cancer molecular subtypes, NSCCL showed the highest grade of edema ( = 0.01). Compared with the ellipsoidal method of volume calculation, the AI machine obtained greater values when measuring lesions of the occipital and temporal lobes ( = 0.01). : Although extremely useful in radiomics analysis, automated segmentation applied alone could effectively differentiate GBM and BM on a conventional MRI, calculating the ratio between their variable components (solid, necrotic and peripheral edema). Other studies applied to a broader set of participants are necessary to further evaluate the efficacy of automated segmentation.