Romanu Ramona, Liga Sergio, Tripon Maria Roberta, Huiban Florin, Iliescu Dan, Dehelean Cristina Adriana, Camelia Tulcan
Doctoral School Engineering of Plant and Animal Resources, University of Life Sciences "King Mihai I" from Timișoara, Aradului Street No. 119, 300645 Timisoara, Romania.
Research Center for Pharmaco-Toxicological Evaluation, "Victor Babeș" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
Plants (Basel). 2025 Aug 23;14(17):2627. doi: 10.3390/plants14172627.
Phytochemistry serves as a vital bridge between traditional medicinal knowledge and modern scientific research, with important implications for pharmaceutical and industrial applications. This review offers an updated and integrated perspective on (greater celandine), focusing on its isoquinoline alkaloids-the principal bioactive constituents-alongside emerging phytochemicals (e.g., lignanamides, polyphenols). Detailed biosynthetic pathways of isoquinoline alkaloids are described, tracing their formation from the shikimate pathway to multiple structural subclasses. Reported biological activities include anticancer, antioxidant, anti-inflammatory, antimicrobial, antiviral, and immunomodulatory effects. A bibliometric analysis was conducted using VOSviewer software (Scopus dataset, 2015-2025), enabling the identification of major research themes and temporal trends. These research tools supported a structured and data-driven overview of the current scientific landscape. However, additional studies are needed to optimize its therapeutic use while ensuring efficacy and safety.
植物化学是传统医学知识与现代科学研究之间的重要桥梁，对制药和工业应用具有重要意义。本综述提供了关于白屈菜的最新综合观点，重点关注其异喹啉生物碱（主要生物活性成分）以及新出现的植物化学物质（如木脂酰胺、多酚）。文中描述了异喹啉生物碱的详细生物合成途径，追溯了它们从莽草酸途径到多个结构亚类的形成过程。报道的生物活性包括抗癌、抗氧化、抗炎、抗菌、抗病毒和免疫调节作用。使用VOSviewer软件（Scopus数据集，2015 - 2025年）进行了文献计量分析，从而确定了主要研究主题和时间趋势。这些研究工具支持了对当前科学状况的结构化和数据驱动的概述。然而，还需要进行更多研究，以优化其治疗用途，同时确保疗效和安全性。
