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来自药用蘑菇的功能化胶束膜作为有前景的自生长生物支架

Functionalized Micellar Membranes from Medicinal Mushrooms as Promising Self-Growing Bioscaffolds.

作者信息

Kučuk Nika, Primožič Mateja, Knez Željko, Leitgeb Maja

机构信息

Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.

Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.

出版信息

Polymers (Basel). 2025 Aug 28;17(17):2334. doi: 10.3390/polym17172334.

DOI:10.3390/polym17172334
PMID:40942252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12431496/
Abstract

Micellar or mycelial membranes from medicinal mushrooms are self-growing fibrous polymeric biocomposites that are biocompatible, biodegradable, cost-effective, and environmentally friendly. In this study, the cultivation process for the medicinal mushrooms and has been optimized via submerged cultivation to maximize growth and promote the formation of micellar membranes with high water-absorption capacity. Optimal growth conditions were achieved at an alkaline pH in a medium containing malt extract for , while for , these were in a glucose-enriched medium. The hydrophilic underside of the micellar membranes led to a high-water uptake capacity. These membranes exhibited a broad spectrum of functional groups, thermal stability with decomposition temperatures above 260 °C, and a fibrous and porous structure. The micellar membranes from both mushrooms were additionally functionalized with mango peel extract (MPE), resulting in a uniform and gradual release profile, which is an important novelty. They also showed successful antimicrobial activity against and growth. MPE-functionalized micellar membranes are, therefore, innovative biocomposites suitable for various biomedical applications. As they mimic the extracellular matrix of the skin, they are a promising material for tissue engineering, wound healing, and advanced skin materials applications.

摘要

药用蘑菇的胶束或菌丝体膜是自生长的纤维状聚合物生物复合材料，具有生物相容性、可生物降解性、成本效益高和环境友好等特点。在本研究中，通过深层培养对药用蘑菇和的培养过程进行了优化，以实现最大生长并促进具有高吸水能力的胶束膜的形成。对于，在含有麦芽提取物的培养基中，在碱性pH条件下实现了最佳生长条件，而对于，最佳生长条件是在富含葡萄糖的培养基中。胶束膜的亲水底面导致其具有高吸水能力。这些膜具有广泛的官能团，分解温度高于260°C的热稳定性，以及纤维状和多孔结构。两种蘑菇的胶束膜还用芒果皮提取物（MPE）进行了额外的功能化，从而产生了均匀且逐渐释放的特性，这是一个重要的新颖之处。它们还对和的生长表现出成功的抗菌活性。因此，MPE功能化的胶束膜是适用于各种生物医学应用的创新生物复合材料。由于它们模仿皮肤的细胞外基质，它们是用于组织工程、伤口愈合和先进皮肤材料应用的有前途的材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/be39c478b0c6/polymers-17-02334-g019.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/fe2673c24e11/polymers-17-02334-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/be39c478b0c6/polymers-17-02334-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/ab8a3a61b37d/polymers-17-02334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/2051a3b005c9/polymers-17-02334-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/c07083ff1632/polymers-17-02334-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/cc5b93d1eba6/polymers-17-02334-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/7705787f6928/polymers-17-02334-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/868f3465acc6/polymers-17-02334-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/554e5589d32d/polymers-17-02334-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/8036c804a172/polymers-17-02334-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/64ce40eb329f/polymers-17-02334-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/19d8ac82e374/polymers-17-02334-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/bdbdf315a356/polymers-17-02334-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/199721cbe509/polymers-17-02334-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/d13d1e17dcff/polymers-17-02334-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/fe2673c24e11/polymers-17-02334-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa26/12431496/be39c478b0c6/polymers-17-02334-g019.jpg

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