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基因的7重复(7R)变体与医学专业人员应对压力的方式——一项初步研究

The 7-Repeat (7R) Variant of the Gene and Ways of Coping with Stress in Medical Professionals-A Preliminary Study.

作者信息

Bliźniewska-Kowalska Katarzyna, Gałecki Piotr, Czarny Piotr, Szemraj Janusz, Kołodziej Łukasz, Gałecka Małgorzata

机构信息

Department of Adult Psychiatry, Medical University of Lodz, 91-229 Lodz, Poland.

Department of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.

出版信息

Int J Mol Sci. 2025 Sep 5;26(17):8653. doi: 10.3390/ijms26178653.

Abstract

How we deal with stress and certain traits of our personality can be influenced not only by psycho-social factors, but also by biological factors, including genetics. Research studies suggest that the long allele of the gene (-7R) is associated with novelty seeking and risk taking-features potentially important for healthcare workers. The aim of this study was to assess the -7R polymorphism and its impact on propensity for risk taking and ways of coping with stress in medical professionals This preliminary study involved 82 volunteers from among active healthcare professionals, including 33 medical doctors (MDs). All participants were asked to fill out psychological questionnaires for assessment of their stress-coping strategies (Mini-COPE) and risk-taking propensity (IVE). A swab of the inside of the cheek was taken from the study participants to determine the polymorphism within the gene for the dopamine D4 receptor gene (). In our study, medical doctors (MDs) tend to have the -7R allele more often than other medical professionals. Our study also indicates that -R7 allele carriers are significantly less likely to use stimulants and other substances to help themselves with stress coping and less likely to expect emotional support. The gene polymorphism may be important for the development of specific personality traits and ways of coping with stress. However, further research with larger numbers of participants is needed.

摘要

我们应对压力的方式以及人格的某些特质不仅会受到心理社会因素的影响,还会受到包括遗传学在内的生物学因素的影响。研究表明,基因(-7R)的长等位基因与寻求新奇和冒险行为相关——这些特征对医护人员可能具有重要意义。本研究的目的是评估-7R多态性及其对医疗专业人员冒险倾向和应对压力方式的影响。这项初步研究涉及82名在职医护人员志愿者,其中包括33名医生(MDs)。所有参与者都被要求填写心理问卷,以评估他们的压力应对策略(Mini-COPE)和冒险倾向(IVE)。从研究参与者的口腔内侧采集拭子,以确定多巴胺D4受体基因()内的多态性。在我们的研究中,医生(MDs)比其他医疗专业人员更常携带-7R等位基因。我们的研究还表明,-R7等位基因携带者使用兴奋剂和其他物质来帮助自己应对压力的可能性显著降低,且不太可能期望获得情感支持。该基因多态性可能对特定人格特质的发展和应对压力的方式具有重要意义。然而,需要更多参与者进行进一步研究。

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