The Effects of Whole-Body Vibration on Spasticity in Stroke: A Systematic Review and Meta-Analysis.

: Spasticity is a common and disabling sequela of stroke that limits voluntary movement and functional recovery. Vibration therapy (VT) has been proposed as a non-invasive neuromodulatory intervention, but the existing studies report inconsistent outcomes due to methodological heterogeneity. This study aimed to evaluate the overall effectiveness of VT in reducing post-stroke spasticity and to identify optimal stimulation parameters via meta-analytic and meta-regression approaches. : A systematic review and meta-analysis were conducted following the PRISMA 2020 guidelines. Standardized effect sizes (Hedges' g) were calculated based on the within-group pre-post changes and compared across the groups. Meta-regression and subgroup analyses explored seven potential moderators, including the vibration frequency, amplitude, and time since stroke onset. : Thirteen randomized controlled trials (RCTs) involving whole-body or focal vibration interventions in stroke populations were included. Vibration therapy significantly reduced spasticity, yielding a moderate overall effect size (Hedges' g = -0.50; 95% CI: -0.65 to -0.34; < 0.001). The greatest treatment effects were observed when VT was applied during the late subacute to early chronic phase (6-12 months post-stroke), with low-frequency (<20 Hz) and low-amplitude (≤0.5 mm) stimulation. The frequency, amplitude, and stroke onset emerged as significant moderators ( < 0.05). : Vibration therapy is an effective and clinically meaningful intervention for post-stroke spasticity, particularly when delivered with low-intensity parameters during the optimal recovery window. These findings support the development of individualized VT protocols and provide evidence to guide future rehabilitation strategies.