评估中国多病共存患者的用药知识及其决定因素。

Assessing Medication Literacy and Its Determinants in Chinese Patients with Multimorbidity.

作者信息

Li Xinyi, Shi Changcheng, Liu Lihong, Wu Yibo

机构信息

Department of Pharmacy, China-Japan Friendship Hospital, Beijing, People's Republic of China.

China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

出版信息

Patient Prefer Adherence. 2025 Sep 6;19:2747-2757. doi: 10.2147/PPA.S539753. eCollection 2025.

DOI:10.2147/PPA.S539753

PMID:40948738

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12423441/

Abstract

PURPOSE

To investigate the medication literacy and influencing factors among patients with multimorbidity.

METHODS

A cross-sectional survey was conducted to assess medication literacy using the medication literacy scale in patients with multimorbidity. Data were collected between June 20 and August 31, 2023, using stratified and quota sampling methods. The Wilcoxon tests or Kruskal-Wallis tests, Pearson's correlation analysis, and multiple stepwise linear regression were employed for the analysis.

RESULTS

3,955 patients with multimorbidity were included, with the average medication literacy score of 18.56±4.52 (scale range: 6-30). Younger age groups (18-30, 31-44, 45-59 years) had higher medication literacy than those aged 60 years or older (β = 0.11, 0.14, 0.17 respectively; all <0.01). Higher education levels (middle/secondary degree, college/university degree, postgraduate degree) correlated with higher medication literacy compared to primary or lower education (β =0.21, 0.28, 0.13 respectively; all <0.01). Currently married (β =0.09, <0.01), unmarried (β =0.15, < 0.01), and divorced individuals (β =0.06, < 0.01) all exhibited higher medication literacy compared to widowed individuals. Compared with people living in Eastern China, those in Central/Western China (β =-0.06, -0.07, respectively; all <0.01) had lower medication literacy. People whose area was urban (β =0.07, <0.01) showed higher medication literacy compared with the rural. A higher score of depressive symptoms (β =-0.20, <0.01) was negatively correlated with medication literacy, and a higher level of social support (β = 0.17, <0.01) was positively correlated with medication literacy.

CONCLUSION

It is critically important to improve medication literacy in patients with multimorbidity, particularly by optimizing medication instructions for understanding. Tailored interventions targeting older, less educated, rural, and central/western populations with emphasis on depression management and social support are needed.

STUDY REGISTRATION

ChiCTR2300072573.

摘要

目的

调查患有多种疾病的患者的用药知识水平及其影响因素。

方法

采用横断面调查，使用用药知识水平量表对患有多种疾病的患者的用药知识水平进行评估。于2023年6月20日至8月31日期间，采用分层配额抽样方法收集数据。分析采用Wilcoxon检验或Kruskal-Wallis检验、Pearson相关分析以及多元逐步线性回归。

结果

纳入3955例患有多种疾病的患者，用药知识水平平均得分为18.56±4.52（量表范围：6 - 30）。年龄较小的年龄组（18 - 30岁、31 - 44岁、45 - 59岁）的用药知识水平高于年龄在60岁及以上的患者（β分别为0.11、0.14、0.17；均P<0.01）。与小学及以下学历相比，较高的教育水平（初中/中专学历、大专/本科学历、研究生学历）与较高的用药知识水平相关（β分别为0.21、0.28、0.13；均P<0.01）。目前已婚者（β =0.09，P<0.01）、未婚者（β =0.15，P<0.01）和离异者（β =0.06，P<0.01）的用药知识水平均高于丧偶者。与生活在中国东部的人相比，中国中部/西部的人用药知识水平较低（β分别为 - 0.06、- 0.07；均P<0.01）。居住在城市地区的人用药知识水平高于农村地区的人（β =0.07，P<0.01）。抑郁症状得分较高（β = - 0.20，P<0.01）与用药知识水平呈负相关，社会支持水平较高（β = 0.17，P<0.01）与用药知识水平呈正相关。