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诺卡菌属小面败血症,免疫功能低下的一个指标:病例说明

Nocardia facet sepsis, an indicator of immunocompromise: illustrative case.

作者信息

Dhodapkar Meera, Rosenow Christian, Mechas Charles-Antoine, Freedman Brett

机构信息

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

出版信息

J Neurosurg Case Lessons. 2025 Sep 15;10(11). doi: 10.3171/CASE25220.

DOI:10.3171/CASE25220
PMID:40953497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12435375/
Abstract

BACKGROUND

Septic facet cysts are a rare phenomenon reported in the literature among immunocompromised hosts and may require operative intervention for appropriate source and symptomatic control.

OBSERVATIONS

A 70-year-old male with a past medical history of immunoglobulin A lambda smoldering myeloma degenerative lumbar disease who presented with low back and radicular lower extremity pain was found to have a left L4-5 septic facet cyst with extension to the epidural space. Intraoperative cultures were positive for Nocardia species. Staging workup revealed progression to high-risk-profile multiple myeloma.

LESSONS

Patients with septic facet cysts may require operative intervention for appropriate source control. Nocardia spine infections and septic facet cysts are rare and require investigation of preexisting risk factors and any potential underlying immunocompromise. https://thejns.org/doi/10.3171/CASE25220.

摘要

背景

化脓性小关节囊肿是文献中报道的免疫功能低下宿主中罕见的现象,可能需要手术干预以进行适当的感染源控制和症状控制。

观察结果

一名70岁男性,有免疫球蛋白Aλ冒烟型骨髓瘤、退行性腰椎疾病病史,因腰背痛和下肢放射性疼痛就诊,发现有一个左L4-5化脓性小关节囊肿并延伸至硬膜外间隙。术中培养结果显示诺卡菌属阳性。分期检查显示已进展为高危型多发性骨髓瘤。

经验教训

化脓性小关节囊肿患者可能需要手术干预以进行适当的感染源控制。诺卡菌脊柱感染和化脓性小关节囊肿很罕见,需要调查既往存在的危险因素和任何潜在的免疫功能低下情况。https://thejns.org/doi/10.3171/CASE25220 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/12435375/94a480fdb5f7/CASE25220_figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/12435375/69866a3c6a98/CASE25220_figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/12435375/f18e3b8c73c2/CASE25220_figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/12435375/94a480fdb5f7/CASE25220_figure_3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/12435375/69866a3c6a98/CASE25220_figure_1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/12435375/f18e3b8c73c2/CASE25220_figure_2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ad/12435375/94a480fdb5f7/CASE25220_figure_3.jpg

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Nocardial epidural abscess: A case report.诺卡菌性硬膜外脓肿:一例报告
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Case of multi-drug resistant as the causative agent of cervical spine osteomyelitis in an immunocompetent adult.
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Nocardial spinal epidural abscess with lumbar disc herniation: A case report and review of literature.伴有腰椎间盘突出症的诺卡菌性脊髓硬膜外脓肿:病例报告及文献复习
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Evaluation and Treatment of Lumbar Facet Cysts.腰椎小关节囊肿的评估与治疗
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Diagnostic challenge: bilateral infected lumbar facet cysts--a rare cause of acute lumbar spinal stenosis and back pain.诊断难题:双侧感染性腰椎小关节囊肿——急性腰椎椎管狭窄症和腰痛的罕见病因。
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Immunoglobulin prophylaxis in chronic lymphocytic leukemia and multiple myeloma: systematic review and meta-analysis.慢性淋巴细胞白血病和多发性骨髓瘤中的免疫球蛋白预防:系统评价与荟萃分析
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Eur Spine J. 2006 Aug;15(8):1176-82. doi: 10.1007/s00586-005-0009-4. Epub 2006 Jan 27.
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Lumbar synovial cysts of the spine: an evaluation of surgical outcome.腰椎滑膜囊肿:手术结果评估
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