• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

红景天苷通过减轻炎症反应和增强人牙周膜干细胞的成骨分化来改善牙周炎。

Salidroside Improves Periodontitis by Mitigating Inflammatory Reactions and Enhancing Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.

作者信息

Li Wanheng, Liu Qing, Chen Siyu, Zhi Mengfan, Yang Peng, Zhang Yuxing, Wu Zhaoyan, Zhang Jun, Feng Qiang

机构信息

Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.

Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, People's Republic of China.

出版信息

Drug Des Devel Ther. 2025 Sep 10;19:8097-8114. doi: 10.2147/DDDT.S530311. eCollection 2025.

DOI:10.2147/DDDT.S530311
PMID:40955307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12433638/
Abstract

PURPOSE

Salidroside (Sal), a significant bioactive compound found in , is documented to possess various pharmacological properties. This study investigated the effects of Sal in alleviating periodontitis.

METHODS

The rat periodontitis model was utilized to assess the therapeutic impact of Sal on periodontitis. Human periodontal ligament stem cells (hPDLSCs) were used to investigate the effect of Sal on lipopolysaccharide (LPS)-inhibited osteogenic differentiation. RNA sequencing (RNA-seq), and Western blot were employed to analyze the genes and proteins impacted by Sal treatment.

RESULTS

Sal significantly alleviated the alveolar bone loss and gingival inflammation in rats periodontitis model. Sal demonstrated a dose-dependent pattern of promoting osteogenesis on hPDLSCs. A concentration of 0.5 μM Sal could effectively counteract the impact of LPS on osteogenic differentiation. Mechanically, Sal inhibited the ratios of phospho-IκBα(p-IκBα)/IκBα and phospho-p65(p-p65)/p65 in Nuclear Factor kappa-B (NF-κB) pathway and reduced the expressions of interleukin-6 (IL-6) and interleukin-8 (IL-8). Sal increased the expression of lymphoid enhancer-binding factor 1 (LEF1).

CONCLUSION

Sal promoted the osteogenic differentiation by inhibiting the activation of the NF-κB pathway and increasing the expression of LEF1.

摘要

目的

红景天苷（Sal）是 中发现的一种重要生物活性化合物，已被证明具有多种药理特性。本研究调查了红景天苷在减轻牙周炎方面的作用。

方法

利用大鼠牙周炎模型评估红景天苷对牙周炎的治疗效果。使用人牙周膜干细胞（hPDLSCs）研究红景天苷对脂多糖（LPS）抑制的成骨分化的影响。采用RNA测序（RNA-seq）和蛋白质免疫印迹法分析红景天苷处理后受影响的基因和蛋白质。

结果

红景天苷显著减轻了大鼠牙周炎模型中的牙槽骨丢失和牙龈炎症。红景天苷对hPDLSCs的成骨作用呈剂量依赖性。0.5 μM的红景天苷浓度可有效抵消LPS对成骨分化的影响。机制上，红景天苷抑制核因子κB（NF-κB）通路中磷酸化IκBα（p-IκBα）/IκBα和磷酸化p65（p-p65）/p65的比例，并降低白细胞介素-6（IL-6）和白细胞介素-8（IL-8）的表达。红景天苷增加了淋巴样增强因子1（LEF1）的表达。

结论

红景天苷通过抑制NF-κB通路的激活和增加LEF1的表达来促进成骨分化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/cacbae33d5d1/DDDT-19-8097-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/df6c54ace549/DDDT-19-8097-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/53b8c452b08f/DDDT-19-8097-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/90f265c6c636/DDDT-19-8097-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/f157c5801d60/DDDT-19-8097-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/9c72e1ecc800/DDDT-19-8097-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/cacbae33d5d1/DDDT-19-8097-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/df6c54ace549/DDDT-19-8097-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/53b8c452b08f/DDDT-19-8097-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/90f265c6c636/DDDT-19-8097-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/f157c5801d60/DDDT-19-8097-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/9c72e1ecc800/DDDT-19-8097-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25fc/12433638/cacbae33d5d1/DDDT-19-8097-g0006.jpg

相似文献

1
Salidroside Improves Periodontitis by Mitigating Inflammatory Reactions and Enhancing Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.红景天苷通过减轻炎症反应和增强人牙周膜干细胞的成骨分化来改善牙周炎。
Drug Des Devel Ther. 2025 Sep 10;19:8097-8114. doi: 10.2147/DDDT.S530311. eCollection 2025.
2
Human dental follicle cell-derived conditioned media enhance periodontal regeneration by regulating the osteogenic differentiation and inflammation of periodontal ligament stem cells and macrophage polarization.人牙囊细胞来源的条件培养基通过调节牙周膜干细胞的成骨分化、炎症反应及巨噬细胞极化来促进牙周再生。
Mol Cell Biochem. 2025 Apr 2. doi: 10.1007/s11010-025-05260-9.
3
Kaempferol combats the osteogenic differentiation damage of periodontal ligament stem cells in periodontitis via regulating EphrinB2-mediated PI3K/Akt and P38 pathways.山奈酚通过调节EphrinB2介导的PI3K/Akt和P38信号通路，对抗牙周炎中牙周膜干细胞的成骨分化损伤。
Phytomedicine. 2025 Jun;141:156733. doi: 10.1016/j.phymed.2025.156733. Epub 2025 Apr 6.
4
BMAL1-downregulation drives PANoptosis and the osteogenic differentiation impairment of PDLSCs by ERK/AP-1 signaling pathway.BMAL1下调通过ERK/AP-1信号通路驱动牙周膜干细胞的PAN凋亡和成骨分化受损。
J Periodontol. 2025 Apr 21. doi: 10.1002/JPER.24-0497.
5
Silencing FOXA1 suppresses inflammation caused by LPS and promotes osteogenic differentiation of periodontal ligament stem cells through the TLR4/MyD88/NF-κB pathway.沉默FOXA1可抑制脂多糖引起的炎症，并通过TLR4/MyD88/NF-κB途径促进牙周膜干细胞的成骨分化。
Biomol Biomed. 2025 Apr 3;25(5):1138-1149. doi: 10.17305/bb.2024.11367.
6
Bmi-1 alleviates alveolar bone resorption through the regulation of autophagy.Bmi-1通过自噬调节减轻牙槽骨吸收。
J Periodontol. 2024 Sep 23. doi: 10.1002/JPER.23-0796.
7
PKCβ expression contributes to M1 macrophage-induced impairment in the osteogenic differentiation of periodontal ligament stem cells.蛋白激酶Cβ（PKCβ）的表达导致M1巨噬细胞诱导的牙周膜干细胞成骨分化受损。
In Vitro Cell Dev Biol Anim. 2025 Jun 17. doi: 10.1007/s11626-025-01032-3.
8
AS2863619 boosts osteogenesis in periodontal ligament stem cells and mitigates inflammatory impairment.AS2863619可促进牙周膜干细胞的成骨作用并减轻炎症损伤。
Int Immunopharmacol. 2025 Jun 17;161:115101. doi: 10.1016/j.intimp.2025.115101.
9
Role of SIRT6 in Chronic Periodontitis and Osteogenic Differentiation of Periodontal Ligament Stem Cells.SIRT6在慢性牙周炎及牙周膜干细胞成骨分化中的作用
Int Dent J. 2025 Aug 2;75(5):100926. doi: 10.1016/j.identj.2025.100926.
10
Progesterone-induced activation of progesterone receptor alleviates alveolar bone resorption and inflammatory response in periodontitis.孕酮诱导的孕酮受体激活可减轻牙周炎中的牙槽骨吸收和炎症反应。
Clin Oral Investig. 2025 Sep 11;29(10):446. doi: 10.1007/s00784-025-06473-4.

本文引用的文献

1
NF-κB in inflammation and cancer.炎症与癌症中的核因子-κB
Cell Mol Immunol. 2025 Jun 25. doi: 10.1038/s41423-025-01310-w.
2
The extracellular vesicle-based treatment: a developing strategy for periodontal diseases.基于细胞外囊泡的治疗：一种牙周疾病的发展策略。
Front Immunol. 2025 May 29;16:1480292. doi: 10.3389/fimmu.2025.1480292. eCollection 2025.
3
Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition.牙周炎发病机制的微生物学和分子学方面：一种感染诱导的炎症状态。
Front Cell Infect Microbiol. 2025 May 8;15:1533658. doi: 10.3389/fcimb.2025.1533658. eCollection 2025.
4
The dual role of IL-17 in periodontitis regulating immunity and bone homeostasis.白细胞介素-17在牙周炎中调节免疫和骨稳态的双重作用。
Front Immunol. 2025 Apr 3;16:1578635. doi: 10.3389/fimmu.2025.1578635. eCollection 2025.
5
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.红景天苷通过硬脂酰辅酶A去饱和酶1（SCD1）介导的脂肪生成和核受体辅助激活因子4（NCOA4）介导的铁自噬使三阴性乳腺癌对铁死亡敏感。
J Adv Res. 2024 Sep 29. doi: 10.1016/j.jare.2024.09.027.
6
Epidemiological associations between periodontitis and cancer.牙周炎与癌症的流行病学关联。
Periodontol 2000. 2024 Oct;96(1):74-82. doi: 10.1111/prd.12599. Epub 2024 Sep 20.
7
Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine.稳态医学时代的口腔微生物群、牙周病和全身性骨相关疾病
J Adv Res. 2024 Aug 17. doi: 10.1016/j.jare.2024.08.019.
8
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis.成骨细胞谱系定向分化、分化、骨形成和体内平衡的细胞信号传导与转录调控。
Cell Discov. 2024 Jul 2;10(1):71. doi: 10.1038/s41421-024-00689-6.
9
Galectin-3 inhibition alleviated LPS-induced periodontal inflammation in gingival fibroblasts and experimental periodontitis mice.半乳糖凝集素-3 抑制减轻脂多糖诱导的牙龈成纤维细胞牙周炎症和实验性牙周炎小鼠的牙周炎症。
Clin Sci (Lond). 2024 Jun 19;138(12):725-739. doi: 10.1042/CS20240036.
10
Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiation.成骨分化过程中Wnt与骨形态发生蛋白信号通路之间的相互作用。
World J Stem Cells. 2024 Feb 26;16(2):102-113. doi: 10.4252/wjsc.v16.i2.102.