Islam Md Ashiqul, Alam Md Ashraful, Ahmed Shahriar, Rakib Ahmed, Uddin Md Giash, Islam Mohammad Nazmul, Etu Fariha Sultana, Masud Md Iftikhar Uddin, Uddin S M Naim
Department of Pharmacy Mawlana Bhashani Science and Technology University Tangail Bangladesh.
Department of Pharmacy University of Chittagong Chittagong Bangladesh.
Health Sci Rep. 2025 Sep 14;8(9):e71222. doi: 10.1002/hsr2.71222. eCollection 2025 Sep.
Fibromyalgia is an emerging health concern in Bangladesh, with symptoms that tend to worsen over time. This study sought to measure serum lipid peroxidation, nonenzymatic antioxidant, C-reactive protein (CRP), macro-minerals, and trace elements in fibromyalgia syndrome (FMS) patients to explore their association with disease progression.
The investigation involved 50 fibromyalgia patients (cases) and 50 healthy individuals (controls) in Bangladesh. Serum malondialdehyde (MDA) was measured to assess lipid peroxidation utilizing spectrophotometry. UV spectrophotometric technique was employed for the determination of vitamin C, while serum levels of macro-minerals (Mg and Ca) and trace elements (Zn and Cu) were quantified using atomic absorption spectroscopy. CRP level was ascertained by using CRP-Latex agglutination assay.
Our study identified markedly increased levels of MDA (4.26 ± 0.04 nmol/mL, < 0.001), CRP (17.13 ± 8.95 mg/L, < 0.001), and notably reduced vitamin C levels (17.6 ± 1.84 µmol/L, < 0.001) in the FMS group compared with healthy controls (HC). Mean serum values of Ca, Mg, Zn, and Cu were 7725.2 ± 202.43 µg/dL, 1173.6 ± 6.00 µg/dL, 69.62 ± 0.69 µg/dL, and 144.66 ± 0.80 µg/dL for the patient group and 8718 ± 169.95 µg/dL, 1619.4 ± 10.32 µg/dL, 91.4 ± 0.86 µg/dL, and 115.28 ± 0.96 µg/dL for the control group, respectively. A significant difference was observed for all macro-minerals and trace elements between the FMS and the HC groups. Moreover, Pearson's correlation study revealed a significant positive and negative correlation between Mg and Cu in the FMS group ( = 0.328, = 0.02) and in the HC group ( = -0.305, = 0.032), respectively.
The findings suggest that elevated serum MDA, depleted serum concentrations of vitamin C, and altered trace elements and macro-mineral concentrations characterize the FMS patients in Bangladesh.
纤维肌痛症在孟加拉国正成为一个日益受到关注的健康问题，其症状往往会随着时间的推移而恶化。本研究旨在测量纤维肌痛综合征（FMS）患者的血清脂质过氧化、非酶抗氧化剂、C反应蛋白（CRP）、常量矿物质和微量元素，以探讨它们与疾病进展的关联。
该调查涉及孟加拉国的50名纤维肌痛患者（病例组）和50名健康个体（对照组）。采用分光光度法测量血清丙二醛（MDA）以评估脂质过氧化。利用紫外分光光度技术测定维生素C，同时使用原子吸收光谱法定量血清常量矿物质（镁和钙）和微量元素（锌和铜）的水平。通过CRP - 乳胶凝集试验确定CRP水平。
我们的研究发现，与健康对照组（HC）相比，FMS组的MDA水平显著升高（4.26±0.04 nmol/mL，P<0.001）、CRP水平显著升高（17.13±8.95 mg/L，P<0.001），而维生素C水平显著降低（17.6±1.84 μmol/L，P<0.001）。患者组钙、镁、锌和铜的血清均值分别为7725.2±202.43 μg/dL、1173.6±6.00 μg/dL、69.62±0.69 μg/dL和144.66±0.80 μg/dL，对照组分别为8718±169.95 μg/dL、1619.4±10.32 μg/dL、91.4±0.86 μg/dL和115.28±0.96 μg/dL。FMS组与HC组之间所有常量矿物质和微量元素均存在显著差异。此外，Pearson相关性研究显示，FMS组中镁与铜之间存在显著正相关（r = 0.328，P = 0.02），HC组中镁与铜之间存在显著负相关（r = -0.305，P = 0.032）。
研究结果表明，血清MDA升高、血清维生素C浓度降低以及微量元素和常量矿物质浓度改变是孟加拉国FMS患者的特征。
