Jaradat Maram, Kolker Justine, Owais Arwa, Guzman-Armstrong Sandra, Haes Amanda, Anamali Sindhura, Comnick Carissa, Zeng Erliang, Kanellis Michael
Department of Conservative Dentistry, Jordan University of Science and Technology, Irbid, Jordan.
Department of Operative Dentistry, College of Dentistry and Dental Clinics, Iowa, USA.
J Conserv Dent Endod. 2025 Sep;28(9):892-898. doi: 10.4103/JCDE.JCDE_83_25. Epub 2025 Sep 5.
Despite the advancement in dental care, dental caries remains the most prevalent oral disease, necessitating the need for effective, preventive, and minimally invasive treatment options. The aim of this study was to evaluate the effectiveness of silver diamine fluoride (SDF) in arresting initial approximal carious lesions in adults.
This study was a randomized, triple-blinded, placebo-controlled clinical trial. Participants were randomly assigned to one of two arms (A or B). One randomly selected lesion received either treatment (SDF solution) or placebo (water). Lesions were followed at 6- and 12-month using bitewing radiographs. Lesion progression was assessed via three evaluation methods: (1) pairwise comparison of bitewing radiographs (visual assessment), (2) assessment of subtraction radiographs (digital subtraction radiography [DSR]), and (3) histogram analysis of subtraction radiographs (HA). All the statistical analyses were performed using R software (the R Foundation, Vienna, Austria) at the 5% significance level.
Over 12-month period, more than 90% of the lesions were arrested in both groups. The SDF group performed significantly better according to the DSR method between baseline and 6 months (P = 0.05). There were no significant differences between the groups at the 12-month follow-up.
SDF treatment was superior in arresting initial approximal caries lesions during the first 6 months of use. This is significant for disease control in high-risk individuals who present to the clinic with multiple initial approximal caries lesions. Further studies are needed to confirm its effectiveness.
尽管牙科护理有所进步，但龋齿仍是最普遍的口腔疾病，因此需要有效的、预防性的和微创的治疗方案。本研究的目的是评估氟化银胺（SDF）在阻止成人初期邻面龋损方面的有效性。
本研究是一项随机、三盲、安慰剂对照的临床试验。参与者被随机分配到两个组（A组或B组）之一。随机选择的一个龋损接受治疗（SDF溶液）或安慰剂（水）。使用咬合翼片在6个月和12个月时对龋损进行随访。通过三种评估方法评估龋损进展：（1）咬合翼片的两两比较（视觉评估），（2）减影X线片评估（数字减影X线摄影[DSR]），以及（3）减影X线片的直方图分析（HA）。所有统计分析均使用R软件（R基金会，奥地利维也纳）在5%的显著性水平下进行。
在12个月期间，两组中超过90%的龋损得到了控制。根据DSR方法，SDF组在基线和6个月之间的表现明显更好（P = 0.05）。在12个月随访时，两组之间没有显著差异。
在使用的前6个月，SDF治疗在阻止初期邻面龋损方面更具优势。这对于向诊所就诊的患有多个初期邻面龋损的高危个体的疾病控制具有重要意义。需要进一步研究来证实其有效性。
