结核分枝杆菌的同步复制
Synchronized replication of Mycobacterium tuberculosis.
作者信息
Wayne L G
出版信息
Infect Immun. 1977 Sep;17(3):528-30. doi: 10.1128/iai.17.3.528-530.1977.
Abstract
When Mycobacterium tuberculosis was grown in Tween-albumin broth without any agitation, the bacilli replicated in the upper, oxygen-rich portion of the medium at a rate that was just balanced by the rate at which the bacilli settled toward the bottom of the tube. When the organisms that accumulated in the sediment were suspended and diluted into fresh medium, they exhibited synchronous replication. The bacilli initiated ribonucleic acid synthesis immediately upon suspension, but marked deoxyribonucleic acid synthesis was not apparent until after the first cellular division was completed, about 14 h after suspension.
摘要
当结核分枝杆菌在不含任何搅动的吐温 - 白蛋白肉汤中培养时，杆菌在培养基富含氧气的上部区域进行复制，其复制速率恰好与杆菌沉降至试管底部的速率相平衡。当沉淀中积累的菌体被悬浮并稀释到新鲜培养基中时，它们表现出同步复制。杆菌在悬浮后立即开始核糖核酸合成，但明显的脱氧核糖核酸合成直到第一次细胞分裂完成后才显现，悬浮后约14小时。
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