Xiao Di, Huang Yingyi, Fang Zhonghan, Liu Danyang, Wang Qi, Xu Yichen, Li Ping, Li Jiang
School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510182, China.
Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, China.
Mater Today Bio. 2025 Aug 21;34:102221. doi: 10.1016/j.mtbio.2025.102221. eCollection 2025 Oct.
The skin, the body's largest organ, acts as the primary defense against external environmental threats and is crucial for maintaining homeostasis. It encounters various challenges in healing diverse wound types, including mechanical injuries, diabetic ulcers, and burns. Zinc oxide nanoparticles (ZnO NPs) are increasingly recognized for their unique properties and potential in promoting skin wound healing. However, the effects and specific mechanisms of ZnO NPs in pathological microenvironments remain poorly understood. This systematic review aims to elucidate the roles of ZnO NPs in the wound healing processes associated with mechanical injuries, diabetic ulcers, and burns. Relevant literature was identified using defined search terms related to skin wounds treated by ZnO NPs. The findings across studies show that ZnO-loaded dressings exhibit superior efficacy in promoting tissue regeneration. At appropriate concentrations, ZnO NPs demonstrate superior performance compared to non-ZnO materials in promoting wound healing. Additionally, ZnO NP-containing materials possess characteristics such as antibacterial and anti-inflammatory properties. The mechanisms underlying the promotion of wound healing by ZnO in mechanical traumas, diabetic ulcers, and burns are summarized, highlighting its promising potential for tissue regeneration applications.
皮肤是人体最大的器官，作为抵御外部环境威胁的主要防线，对于维持体内平衡至关重要。它在愈合各种伤口类型时面临各种挑战，包括机械损伤、糖尿病溃疡和烧伤。氧化锌纳米颗粒（ZnO NPs）因其独特的性质和促进皮肤伤口愈合的潜力而越来越受到认可。然而，ZnO NPs在病理微环境中的作用和具体机制仍知之甚少。本系统综述旨在阐明ZnO NPs在与机械损伤、糖尿病溃疡和烧伤相关的伤口愈合过程中的作用。使用与ZnO NPs治疗的皮肤伤口相关的特定搜索词确定相关文献。各项研究的结果表明，负载ZnO的敷料在促进组织再生方面表现出卓越的功效。在适当浓度下，与非ZnO材料相比，ZnO NPs在促进伤口愈合方面表现出更优异的性能。此外，含ZnO NP的材料具有抗菌和抗炎等特性。总结了ZnO在机械创伤、糖尿病溃疡和烧伤中促进伤口愈合的潜在机制，突出了其在组织再生应用方面的广阔前景。
