Ruan Gechong, Sun Yinghao, Yu Ziqing, Bai Xiaoyin, Yang Hong, Qian Jiaming
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China.
Gastroenterol Rep (Oxf). 2025 Sep 12;13:goaf082. doi: 10.1093/gastro/goaf082. eCollection 2025.
Inflammatory bowel disease (IBD) imposes a significant economic and social burden. We aimed to assess the burden of IBD globally, regionally, and nationally.
The incidence, mortality, prevalence, and disability-adjusted life year were obtained from Global Burden of Disease 2021. Estimated annual percentage change, average annual percent change, and age-period-cohort model were used to access trends. Associations between age-standardized rate (ASR) and socio-demographic index were explored. Predictions were made using Bayesian age-period-cohort model and Nordpred.
In 2021, IBD affected 3.8 million people, with ASR of incidence and death of 4.4 and 0.5. The global ASR of incidence increased from 1990 to 2021, while ASR of death, prevalence, and disability-adjusted life year decreased. The age-standardized death rate (ASDR) did not show a significant increase from 2019 to 2021 in most regions and countries. High-incidence regions, such as Western Europe, continued to face significant burdens. East Asian, especially China, was experiencing a sharp increase in incidence. ASR of incidence and death increased with rising socio-demographic index. By 2035, the ASR of incidence and death of IBD will gradually decline.
The global burden of IBD remains severe with changing epidemiological trends. Reducing the burden requires changes in public health policies, disease prevention, and healthcare services.
炎症性肠病（IBD）带来了巨大的经济和社会负担。我们旨在评估全球、区域和国家层面的IBD负担。
发病率、死亡率、患病率和伤残调整生命年数据来自《2021年全球疾病负担》。使用估计年百分比变化、平均年百分比变化和年龄-时期-队列模型来分析趋势。探讨了年龄标准化率（ASR）与社会人口指数之间的关联。使用贝叶斯年龄-时期-队列模型和Nordpred进行预测。
2021年，IBD影响了380万人，发病率和死亡率的ASR分别为4.4和0.5。从1990年到2021年，全球发病率ASR上升，而死亡率、患病率和伤残调整生命年的ASR下降。在大多数地区和国家，2019年至2021年期间年龄标准化死亡率（ASDR）没有显著上升。西欧等高发病率地区继续面临重大负担。东亚，尤其是中国，发病率正在急剧上升。发病率和死亡率的ASR随着社会人口指数的上升而增加。到2035年，IBD的发病率和死亡率ASR将逐渐下降。
随着流行病学趋势的变化，IBD的全球负担仍然严重。减轻负担需要改变公共卫生政策、疾病预防和医疗服务。
