Craig G T, Franklin C D
J Oral Pathol. 1977 Sep;6(5):268-77. doi: 10.1111/j.1600-0714.1977.tb01649.x.
Hamster cheek pouches were painted thrice weekly with 50% v/v turpentine in liquid paraffin over periods ranging from 1 day to 16 weeks. Pouch mucosa was examined histologically for changes and measurements of epithelial thickness were made with a calibrated eyepiece micrometer. An increase in epithelial thickness was first observed 48 hrs. after a single painting and was accompanied by inflammatory changes in both epithelium and connective tissue. Maximal epithelial thickening occurred after 9 weeks of thrice weekly painting. Cheek pouches of animals left without further treatment for up to 1 year following 9 weeks painting were indistinguishable from controls. The epithelial response to treatment with turpentine is that of a reversible benign epithelial hyperplasia with hyperkeratosis.
每周三次用50%（体积/体积）松节油与液状石蜡的混合物涂抹仓鼠颊囊，持续时间从1天至16周不等。对颊囊黏膜进行组织学检查以观察变化，并用校准的目镜测微计测量上皮厚度。单次涂抹后48小时首次观察到上皮厚度增加，同时上皮和结缔组织均出现炎症变化。每周涂抹三次，9周后上皮增厚达到最大值。在9周涂抹后长达1年未接受进一步治疗的动物的颊囊与对照组无明显差异。松节油治疗引起的上皮反应是伴有角化过度的可逆性良性上皮增生。
