Tan Changwu, Wang Xi, Liu Tong, Liu Longqian, Reynaud Alexandre
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Laboratory of Optometry and Vision Sciences, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Invest Ophthalmol Vis Sci. 2025 Sep 2;66(12):54. doi: 10.1167/iovs.66.12.54.
The perceived size of an object can be manipulated by its surroundings. In the current study, we wanted to investigate whether amblyopic patients have normal object size perception and how their perception is affected by abnormal interocular interactions.
Sixteen adult amblyopes and 16 controls participated in this experiment. We measured the Ebbinghaus illusion magnitude with large and small inducers under one binocular, two monocular, and four dichoptic viewing configurations. Exploratory factor analysis was used to extract common structures and underlying mechanisms in different conditions.
The mean Ebbinghaus illusion magnitude in amblyopia was smaller with large inducers (F1,30 = 5.874, P = 0.021) and larger with small inducers (F1,30 = 5.814, P = 0.022) than in controls. For the small-inducer geometry, the interaction effect between groups and viewing configurations (F6,180 = 4.472, P < 0.001) was significant. Compared to the control population, the exploratory factor analysis in amblyopia extracted three more factors mainly accounting for dichoptic viewing configurations.
Amblyopes tended to overestimate the object size relative to controls in the Ebbinghaus illusion, thereby amplifying it in the small-inducer geometry and diminishing it in the large-inducer geometry. Our factor analysis revealed a limited interocular transfer of the Ebbinghaus illusion in amblyopia, suggesting a defective mechanism in local binocular integration circuitry.
物体的感知大小会受到其周围环境的影响。在本研究中，我们想探究弱视患者是否具有正常的物体大小感知，以及他们的感知如何受到异常双眼相互作用的影响。
16名成年弱视患者和16名对照者参与了本实验。我们在单眼、双眼和四种双眼分离观察配置下，使用大小不同的诱导物测量了埃宾浩斯错觉量值。探索性因素分析用于提取不同条件下的共同结构和潜在机制。
与对照组相比，弱视患者在使用大诱导物时平均埃宾浩斯错觉量值较小（F1,30 = 5.874，P = 0.021），而在使用小诱导物时较大（F1,30 = 5.814，P = 0.022）。对于小诱导物几何形状，组间和观察配置之间的交互作用（F6,180 = 4.472，P < 0.001）显著。与对照组相比，弱视患者的探索性因素分析多提取了三个主要解释双眼分离观察配置的因素。
在埃宾浩斯错觉中，弱视患者相对于对照组倾向于高估物体大小，从而在小诱导物几何形状中放大错觉，在大诱导物几何形状中减小错觉。我们的因素分析揭示了弱视患者中埃宾浩斯错觉的双眼间转移有限，提示局部双眼整合电路存在缺陷机制。
