Jaffal Sahar, Thipayarat Aluck, Alqaraleh Samer, Wongwiwat Jakrapop, Supanivatin Pattarin
Pharmacy Department, College of Pharmacy, Amman Arab University, Amman, Jordan.
Department of Food Engineering, Faculty of Food Engineering, King Mongkut's University of Technology Thonburi, Bangkok, 10140, Thailand.
Inflammopharmacology. 2025 Sep 24. doi: 10.1007/s10787-025-01929-1.
Pain and inflammation are complex physiological responses. The drugs that are available in the market have multiple side effects. Thus, the search for safer effective therapeutics became a significant area of research. In this study, Jasmine sambac L. essential oil, which is aromatic and therapeutic in nature, has been studied for its potential anti-inflammatory and anti-nociceptive activities as well as its mechanism of action. The findings from this research indicated that the intraplantar (ipl) administration of jasmine essential oil to the animals produced anti-inflammatory effects in the carrageenan-induced paw edema model. In addition, jasmine essential oil showed significant inhibition of pain responses compared to the control group in the acetic acid-induced writhing test and immersion tail-flick test. These findings suggest that jasmine oil exhibits anti-nociceptive and anti-inflammatory effects in animals. More data are needed to determine its therapeutic value in human clinical trials. The anti-inflammatory and anti-nociceptive effects were mediated by the transient receptor potential vanilloid 1 (TRPV1), a key pain receptor. The chemical composition of jasmine essential oil was analyzed by gas chromatography-mass spectrometry (GC-MS) to determine the bioactive constituents that can be responsible for these effects. The results showed that the oil consists of active constituents with various therapeutic activities as reported in earlier studies. Thus, jasmine essential oil can be utilized as a complementary therapy for pain and inflammation treatment.
疼痛和炎症是复杂的生理反应。市面上现有的药物有多种副作用。因此，寻找更安全有效的治疗方法成为了一个重要的研究领域。在本研究中，对具有芳香性和治疗作用的茉莉精油的潜在抗炎和抗伤害感受活性及其作用机制进行了研究。该研究的结果表明，向动物足底内注射茉莉精油在角叉菜胶诱导的爪肿胀模型中产生了抗炎作用。此外，在醋酸诱导的扭体试验和浸尾甩尾试验中，与对照组相比，茉莉精油对疼痛反应有显著抑制作用。这些发现表明茉莉精油在动物中表现出抗伤害感受和抗炎作用。需要更多数据来确定其在人体临床试验中的治疗价值。抗炎和抗伤害感受作用是由关键的疼痛受体瞬时受体电位香草酸受体1（TRPV1）介导的。通过气相色谱-质谱联用（GC-MS）分析了茉莉精油的化学成分，以确定可能导致这些作用的生物活性成分。结果表明，该精油含有如早期研究所报道的具有各种治疗活性的活性成分。因此，茉莉精油可作为疼痛和炎症治疗的辅助疗法。
