Li Jie, Yang Zhaoyang, Jiang Jiuming, Gong Lihua, Li Meng
MRI Room of Qingdao Jiaozhou Central Hospital, Qingdao People's Hospital Group (Jiaozhou), Jiaozhou, Shandong, China.
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Oncol. 2025 Sep 9;15:1602577. doi: 10.3389/fonc.2025.1602577. eCollection 2025.
This study presents a rare case of acinar soft tissue sarcoma and provides a detailed analysis of its multi-parameter quantitative functional MRI (fMRI) characteristics. The patient, a 16-year-old male, was diagnosed with acinar soft tissue sarcoma after presenting with a progressively enlarging mass in the right thigh. To determine the extent and nature of the lesion, MRI examinations were performed using conventional plain scans, contrast-enhanced scans, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and intravoxel incoherent motion (IVIM) for quantitative analysis. Functional MRI imaging not only provides crucial diagnostic and differential diagnostic information for acinar soft tissue sarcoma, but also reveals through DCE-MRI and IVIM imaging indicators that ASPS exhibits high cellular density, increased vascular permeability, and abundant neovascularization. The local microcirculation characteristics offer vital insights into the tumor's biological behavior and prognosis. Furthermore, functional MRI aids in precise diagnosis while providing references for surgical planning, postoperative adjuvant therapy, long-term follow-up evaluation, and recurrence risk prediction.
本研究报告了一例罕见的腺泡状软组织肉瘤病例,并对其多参数定量功能磁共振成像(fMRI)特征进行了详细分析。该患者为一名16岁男性,因右大腿肿物逐渐增大就诊,被诊断为腺泡状软组织肉瘤。为确定病变的范围和性质,采用常规平扫、增强扫描、动态对比增强磁共振成像(DCE-MRI)和体素内不相干运动(IVIM)进行MRI检查以进行定量分析。功能磁共振成像不仅为腺泡状软组织肉瘤提供了关键的诊断和鉴别诊断信息,还通过DCE-MRI和IVIM成像指标显示,腺泡状软组织肉瘤表现为高细胞密度、血管通透性增加和丰富的新生血管形成。局部微循环特征为了解肿瘤的生物学行为和预后提供了重要线索。此外,功能磁共振成像有助于精确诊断,同时为手术规划、术后辅助治疗、长期随访评估和复发风险预测提供参考。