Smith A H, Macphee I W
Gut. 1971 Jan;12(1):20-6. doi: 10.1136/gut.12.1.20.
Fifteen patients with ulcerative colitis and 11 patients with ulcerative proctitis have been observed and studied for periods ranging from one to 15 years. It is suggested that the clinical course of the two disorders is quite distinct. Further, while the serum immunoglobulins were within normal limits in ulcerative proctitis, significant increases in the serum alpha(2)-, beta-, and gamma-globulins and in the IgA and IgG concentrations were found in ulcerative colitis. Despite total colectomy for ulcerative colitis, the serum IgG and IgA concentration remained high and even after subsequent rectal resection the relative IgA concentration continued to increase. The significance of these findings is discussed.
对15例溃疡性结肠炎患者和11例溃疡性直肠炎患者进行了观察和研究，观察时间为1至15年。结果表明，这两种疾病的临床病程截然不同。此外，溃疡性直肠炎患者的血清免疫球蛋白在正常范围内，而溃疡性结肠炎患者的血清α2、β和γ球蛋白以及IgA和IgG浓度显著升高。尽管溃疡性结肠炎患者接受了全结肠切除术，但血清IgG和IgA浓度仍居高不下，即使在随后的直肠切除术后，相对IgA浓度仍持续升高。本文讨论了这些发现的意义。
