溃疡性结肠炎和特发性直肠炎全身免疫参数的比较分析：柳氮磺胺吡啶的体内和体外作用
Comparative analysis of systemic immunological parameters in ulcerative colitis and idiopathic proctitis: effects of sulfasalazine in vivo and in vitro.
作者信息
Rubinstein A, Das K M, Melamed J, Murphy R A
出版信息
Clin Exp Immunol. 1978 Aug;33(2):217-24.
Abstract
Comparative analysis of the systemic immunity revealed similarities between ulcerative colitis and idiopathic proctitis. In the active stage of both diseases, circulating complement receptor positive cells were increased whereas T-cell percentages and lymphocyte functions were decreased. In severe forms of ulcerative colitis and idiopathic proctitis circulating EAC-phagocytosing esterase positive cells, indicative of activated monocytes, were demonstrated. Successful treatment with salicylazosulfapyridine (SASP) reversed these immunological changes. Incubation of SASP and its metabolites with leucocytes from patients and control subjects, in concentrations similar to those demonstrated in sera from patients treated with SASP, did not alter the immunological changes.
摘要
对全身免疫的比较分析显示，溃疡性结肠炎和特发性直肠炎之间存在相似之处。在这两种疾病的活动期，循环补体受体阳性细胞增加，而T细胞百分比和淋巴细胞功能下降。在溃疡性结肠炎和特发性直肠炎的严重形式中，发现了循环EAC吞噬酯酶阳性细胞，这表明单核细胞被激活。柳氮磺胺吡啶（SASP）治疗成功逆转了这些免疫变化。将SASP及其代谢产物与患者和对照受试者的白细胞一起孵育，其浓度与接受SASP治疗的患者血清中的浓度相似，但并未改变免疫变化。
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