El-Khatib O S, Lebwohl O, Attia A A, Flood C A, Stein J A, Sweeting J G, Whitlock R T, Osserman E F, Holt P R
Am J Dig Dis. 1978 Apr;23(4):297-301. doi: 10.1007/BF01072409.
The serum levels of lysozyme, serum electrophoresis, and serum immunoglobulins were determined prospectively in 101 patients with ulcerative colitis, ulcerative proctitis, Crohn's disease, or nonclassifiable nonspecific inflammatory bowel disease. Although the mean serum lysozyme concentration of patients with Crohn's disease (10.5 +/- 6.8 microgram/ml) and ulcerative colitis (9.6 +/- 4.1 microgram/ml) performed by a standardized lysoplate method was significantly greater than normal controls (6.0 +/- 1.5 microgram/ml), the results did not correlate with the diagnosis nor with the degree of disease activity. Individually separated protein fractions and serum immunoglobulins also did not correlate with the serum lysozyme levels. This study indicates that measurement of the level of serum lysozyme in individual patients is not helpful in determining the cause or degree of activity of nonspecific inflammatory bowel disease.
前瞻性地测定了101例溃疡性结肠炎、溃疡性直肠炎、克罗恩病或无法分类的非特异性炎症性肠病患者的血清溶菌酶水平、血清电泳及血清免疫球蛋白。尽管采用标准化溶菌平板法测得的克罗恩病患者（10.5±6.8微克/毫升）和溃疡性结肠炎患者（9.6±4.1微克/毫升）的平均血清溶菌酶浓度显著高于正常对照组（6.0±1.5微克/毫升），但结果与诊断及疾病活动程度均无相关性。单独分离的蛋白组分和血清免疫球蛋白也与血清溶菌酶水平无关。本研究表明，测定个体患者的血清溶菌酶水平无助于确定非特异性炎症性肠病的病因或活动程度。
